N,N-二甲基-3-氯丙胺合成路线 （共 146 条）
参考文献
Somin,I.N.
Zhurnal Organicheskoi Khimii, 1968 , vol. 4, # 4 p. 128 - 133,122 - 125
反应条件
1: With ethyl bromide; iodine; magnesium in tetrahydrofuran T=70°C; 0.25 h; 2: 1-dimethylamino-3-chloropropane in tetrahydrofuran T=68 - 70°C; Heating / reflux;
参考文献
JUBILANT ORGANOSYS LIMITED
Patent: WO2005/77927 A1, 2005 ;
Location in patent: Page/Page column 10-11 ;
反应条件
magnesium; 1,1-dibromo ethane in tetrahydrofuran
参考文献
Kyowa Hakko Kogyo Co., Ltd.
Patent: US5116863 A1, 1992 ;
US 5116863 A
反应条件
magnesium; 1,1-dibromo ethane in tetrahydrofuran; diethyl ether
参考文献
Kyowa Hakko Kogyo Co., Ltd.
Patent: US5116863 A1, 1992 ;
US 5116863 A
反应条件
ammonium chloride in tetrahydrofuran; water
参考文献
A. H. Robins Company, Incorporated
Patent: US3978129 A1, 1976 ;
反应条件
hydrogenchloride in tetrahydrofuran
参考文献
Calgon Corporation
Patent: US4044054 A1, 1977 ;
反应条件
in tetrahydrofuran; water; benzene
参考文献
Merck and Co., Inc.
Patent: US3972936 A1, 1976 ;
参考文献
Chan, Cecil; Yin, Hong; Garforth, Jacqui; McKie, James H.; Jaouhari, Rabih; Speers, Peter; Douglas, Kenneth T.; Rock, Peter J.; Yardley, Vanessa; Croft, Simon L.; Fairlamb, Alan H.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 2 p. 148 - 156
参考文献
Schmitt et al.
Bulletin de la Societe Chimique de France, 1957 , p. 1474,1480
反应条件
potassium hydroxide; potassium carbonate; 18-crown-6 ether toluene 1.) room temp., 2 h, 2.) reflux, 18 h; Yield given. Multistep reaction;
参考文献
Schmolka; Zimmer
Synthesis, 1984 , vol. NO. 1, p. 29 - 31
