5-(4,4,5,5-四甲基-1,3,2-二噁硼烷-2-基)噻唑合成路线 (共 3 条)
反应条件
potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in 1,4-dioxane T=100°C; 12 h;
参考文献
WO2009/151598 A1, ;
Page/Page column 167 ;
WO 2009/151598 A1
反应条件
1: 2-trimethylsilanyl-thiazole With n-butyllithium in tetrahydrofuran T=-78°C; 0.583333 h; Inert atmosphere; 2: With tri-isopropoxy-borane in tetrahydrofuran T=-78 - 20°C; 2.75 h; Inert atmosphere; 3: 2,3-dimethylbutane-2,3-diol With acetic acid in tetrahydrofuran pH=5; Inert atmosphere; regioselective reaction;
参考文献
Primas, Nicolas; Bouillon, Alexandre; Lancelot, Jean-Charles; El-Kashef, Hussein; Rault, Sylvain
Tetrahedron, 2009 , vol. 65, # 29-30 p. 5739 - 5746
反应条件
tetrakis(triphenylphosphine) palladium(0); sodium carbonate in 1,4-dioxane; water T=80°C; Suzuki coupling; Inert atmosphere;
参考文献
Primas, Nicolas; Bouillon, Alexandre; Lancelot, Jean-Charles; El-Kashef, Hussein; Rault, Sylvain
Tetrahedron, 2009 , vol. 65, # 29-30 p. 5739 - 5746