3,3-四亚甲基戊二酰亚胺合成路线 （共 15 条）
反应条件
ammonium hydroxide in tetrahydrofuran T=190°C;
参考文献
Ishizumi; Kojima; Antoku
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 9 p. 2288 - 2300
反应条件
1: 8-aza-spiro[4.5]decane-7,9-dione With potassium hydroxide in ethanol T=20°C; 2 h; 2: 1,4-dibromo-butane in acetone T=50°C; Gabriel reaction; 8 h; 3: 1-(pyrimidin-2-yl)-piperazine With potassium carbonate in acetone; butan-1-ol 15 h; Reflux;
参考文献
Luo, Hu; Xia, Wei; Qian, Chao; Chen, Xinzhi; He, Chaohong
Research on Chemical Intermediates, 2011 , vol. 37, # 8 p. 1041 - 1045
反应条件
1: tetrabutylammomium bromide; potassium carbonate / dimethyl sulfoxide / 4 h / 80 °C 2: hydrogenchloride; water / dichloromethane / 2.5 h / 20 °C 3: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane / 0.33 h / 20 °C View Scheme
参考文献
Kowalski, Piotr; Jaskowska, Jolanta
Archiv der Pharmazie, 2012 , vol. 345, # 1 p. 81 - 85
参考文献
Flohr, Alexander; Jakob-Roetne, Roland; Norcross, Roger D.; Riemer, Claus
Patent: US2003/149036 A1, 2003 ;
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=0°C; RefluxInert atmosphere;
参考文献
Wang, Jun; Cady, Sarah D.; Balannik, Victoria; Pinto, Lawrence H.; DeGrado, William F.; Hong, Mei
Journal of the American Chemical Society, 2009 , vol. 131, p. 8066 - 8076
反应条件
in N-methyl-acetamide
参考文献
American Home Products Corporation
Patent: US4812567 A1, 1989 ;
反应条件
potassium carbonate; 18-crown-6 ether in xylene 6 h; Heating;
参考文献
Mead Johnson and Company
Patent: US4351939 A1, 1982 ;
反应条件
1: 70 percent / Pd(PPh3)4 / tetrahydrofuran; dimethylsulfoxide 2: 70 percent / H2 / Pd/C / ethyl acetate View Scheme
参考文献
Ishizumi; Kojima; Antoku
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 9 p. 2288 - 2300
反应条件
potassium carbonate; phenylmethyltriethylammonium bromide 1.) xylene, reflux, 3 h, 2.) reflux, 5 h; other imides and catalysts, variation of reaction time, also in toluene; also 1-(2-quinolinyl)piperazine; Product distribution;
参考文献
Cybulski; Chilmonczyk; Szelejewski; Wojtasiewizc; Wrobel
Archiv der Pharmazie, 1992 , vol. 325, # 5 p. 313 - 315
反应条件
potassium carbonate in acetone 10 h; Heating;
参考文献
Ishizumi; Kojima; Antoku
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 9 p. 2288 - 2300
