3-甲基-4-硝基吡啶-N-氧化物合成路线 （共 39 条）
反应条件
acetyl-bromide; acetic acid T=80°C; 3 h; Inert atmosphere;
参考文献
Diemer, Vincent; Chaumeil, Helene; Defoin, Albert; Fort, Alain; Boeglin, Alex; Carre, Christiane
European Journal of Organic Chemistry, 2008 , # 10 p. 1767 - 1776
反应条件
in N,N-dimethyl-formamide T=100°C; 1.5 h;
参考文献
Ganser, Christopher; Lauermann, Eva; Maderer, Annett; Stauder, Torsten; Kramb, Jan-Peter; Plutizki, Stanislav; Kindler, Thomas; Moehler, Markus; Dannhardt, Gerd
Journal of Medicinal Chemistry, 2012 , vol. 55, # 22 p. 9531 - 9540
反应条件
phosphorus tribromide in ethyl acetate 0.5 h; Heating;
参考文献
Spivey, Alan C.; Shukla, Lena; Hayler, Judy F.
Organic Letters, 2007 , vol. 9, # 5 p. 891 - 894
反应条件
1: 2 h; Heating / refluxNeat (no solvent); 2: With sodium carbonate in water T=0°C;
参考文献
WO2008/63625 A2, ;
Page/Page column 134 ;
WO 2008/063625 A2
反应条件
hydrogenchloride; triethylbutylammonium chloride in water; acetonitrile T=65°C; 10 h;
参考文献
Russian Journal of Organic Chemistry, , vol. 44, # 12 p. 1824 - 1830
反应条件
sodium dichromate; anhydrous sulfurous acid T=55°C; 3 h;
参考文献
Leroy; Despres; Bigan; Blondeau
Synthetic Communications, 1996 , vol. 26, # 12 p. 2257 - 2272
反应条件
1: 97 percent / HCl, PCl3 / CHCl3 / 0.33 h / Heating 2: 65 percent / KMnO4 / H2O / 4 h / 80 - 90 °C 3: 63 percent / HCl / 3 h / Heating View Scheme
参考文献
Synthetic Communications, , vol. 26, # 12 p. 2257 - 2272
反应条件
1: 68 percent / H2SO3, sodium dichromate / 3 h / 55 °C 2: 88 percent / H2 / Pd/C / acetic acid / 2280 Torr / 1) 30 deg C, 2 h, 2) 60 deg C, 2 h 3: 49 percent / H2SO4 / 4 h / Heating 4: 90 percent / LiAlH4 / tetrahydrofuran / 1) 35 deg C, 3 h, 2) reflux, 1 h View Scheme
参考文献
Leroy; Despres; Bigan; Blondeau
Synthetic Communications, 1996 , vol. 26, # 12 p. 2257 - 2272
反应条件
1: 97 percent / HCl, PCl3 / CHCl3 / 0.33 h / Heating 2: 65 percent / KMnO4 / H2O / 4 h / 80 - 90 °C View Scheme
参考文献
Synthetic Communications, , vol. 26, # 12 p. 2257 - 2272
反应条件
n-Butyl nitrite; sodium ethanolate
参考文献
Taylor et al.
Journal of the American Chemical Society, 1957 , vol. 79, p. 3549,3550
