3-甲基-4-硝基吡啶-N-氧化物合成路线 （共 39 条）
反应条件
sulfuric acid; nitric acid T=100 - 105°C; 2 h;
参考文献
Spivey, Alan C.; Shukla, Lena; Hayler, Judy F.
Organic Letters, 2007 , vol. 9, # 5 p. 891 - 894
反应条件
sulfuric acid; potassium nitrate in ethyl acetate
反应条件
1: dihydrogen peroxide / acetic acid / 70 °C / Cooling with ice 2: nitric acid / sulfuric acid / 2 h / 0 - 100 °C View Scheme
参考文献
WO2012/160464 A1, ;
WO 2012/160464 A1
参考文献
Journal of Organic Chemistry, , vol. 19, p. 1633,1636
Org. Synth. Coll., , vol. Vol. IV, p. 166
反应条件
1: 81 percent / PCl3 / 3.5 h / T < 0 deg C 2: 63 percent / dimethylformamide / 1 h / 90 °C 3: 91 percent / H2 / 10percent Pd/C / ethanol / 14.7 - 22.07 Torr / 1) 1 h, 20 deg C, 2) 3 h, 60 deg C 4: 1) NaOH, Bu4N*HSO4 / 1) CH2Cl2, 2) 1 h View Scheme
参考文献
Dormoy, Jean-Robert; Heymes, Alain
Tetrahedron, 1993 , vol. 49, # 14 p. 2885 - 2914
反应条件
1: 49 percent / dimethylformamide / 3 h / 150 °C 2: 62 percent / NaIO4 / tetrahydrofuran; H2O / 20 °C 3: 59 percent / H2 / 10 percent Pd-C / methanol / 20 °C / 760 Torr View Scheme
参考文献
Andreani, Aldo; Leoni, Alberto; Locatelli, Alessandra; Morigi, Rita; Rambaldi, Mirella; Pietra, Claudio; Villetti, Gino
European Journal of Medicinal Chemistry, 2000 , vol. 35, # 1 p. 77 - 82
反应条件
1: 95 percent / H2 / Raney Ni / methanol / 4 h / 3361.46 Torr 2: 84 percent / conc. H2SO4; conc. HNO3 / cooling View Scheme
参考文献
Irani, Rostem J.; SantaLucia Jr., John
Nucleosides, Nucleotides and Nucleic Acids, 2002 , vol. 21, # 11-12 p. 737 - 751
反应条件
1: 95 percent / H2 / Raney Ni / methanol / 4 h / 3361.46 Torr 2: 84 percent / conc. H2SO4; conc. HNO3 / cooling 3: 54 percent / conc. H2SO4 / 20 °C 4: 29 percent / SnCl4; conc. HCl / 0.75 h / Heating View Scheme
参考文献
Irani, Rostem J.; SantaLucia Jr., John
Nucleosides, Nucleotides and Nucleic Acids, 2002 , vol. 21, # 11-12 p. 737 - 751
反应条件
1: 86 percent / dimethylformamide / 1.5 h / 140 °C 2: 64 percent / NaIO4 / tetrahydrofuran; H2O / 12 h / 20 °C View Scheme
参考文献
Andreani, Aldo; Leoni, Alberto; Locatelli, Alessandra; Morigi, Rita; Rambaldi, Mirella; Pietra, Claudio; Villetti, Gino
European Journal of Medicinal Chemistry, 2000 , vol. 35, # 1 p. 77 - 82
反应条件
1: 26 percent / conc. H2SO4; Na2Cr2O7*2H2O / 2.5 h / 30 - 40 °C 2: 40 percent / NH4OH; H2 / 10 percent Pd/C / H2O / 2 h / 2585.74 Torr View Scheme
参考文献
Leroy; Despres; Bigan; Blondeau
Synthetic Communications, 1996 , vol. 26, # 12 p. 2257 - 2272
