2,5-二溴-1,4-二甲基苯合成路线 （共 51 条）
反应条件
1: tetrabutylammomium bromide; palladium diacetate; potassium carbonate / water / 2 h / 70 °C
2: pyridine; potassium permanganate / water / 24 h / Reflux
3: thionyl chloride / 5 h / Reflux
4: tetrahydrofuran / 10 h / Inert atmosphere; Reflux
5: hydrogenchloride / dichloromethane; water / 5 h / Reflux
6: bromine; sodium carbonate / dichloromethane; water
View Scheme
参考文献
Pham, Van Chung; Huh, Geun; Kim, Jungahn; Choo, Dong Joon; Lee, Jae Yeol
Bulletin of the Korean Chemical Society, 2011 , vol. 32, # 5 p. 1781 - 1783
反应条件
1: 1,4-dibromo-2,5-dimethylbenzene With n-butyllithium in tetrahydrofuran; hexane
T=-78°C; 0.166667 h;
2: N,N-dimethyl-formamide in tetrahydrofuran; hexane
T=-78 - 20°C; Further stages.;
参考文献
Liu, Ching-Yuan; Knochel, Paul
Journal of Organic Chemistry, 2007 , vol. 72, # 19 p. 7106 - 7115
反应条件
n-butyllithium; isopropylmagnesium chloride in tetrahydrofuran; N,N-dimethyl-formamide
参考文献
ABBVIE INC.; Cusack, Kevin P.; Gordon, Thomas D.; Hoemann, Michael Z.; Ihle, David C.; Li, Bin; Lo Schiavo, Gloria Y.; Somal, Gagandeep K.; Friedman, Michael; Hayes, Martin E.; Bakker, Wouter Iwema
Patent: US2014/179676 A1, 2014 ;
Location in patent: Page/Page column ;
反应条件
tributoxyborane; magnesium in tetrahydrofuran
参考文献
Faury, Thomas; Dumur, Frederic; Clair, Sylvain; Abel, Mathieu; Porte, Louis; Gigmes, Didier
CrystEngComm, 2013 , vol. 15, # 11 p. 2067 - 2075
反应条件
1: aqueous nitric acid
2: aqueous methanol. NaOH-solution; copper-powder
View Scheme
参考文献
Marzin
Journal fuer Praktische Chemie (Leipzig), 1933 , vol. <2> 138, p. 103,106
反应条件
1: 81 percent / dimethylformamide / 48 h / Heating
2: KOH / bis-(2-hydroxy-ethyl) ether / Heating
3: MeSO3H / 10 h / Heating
View Scheme
参考文献
Ngola, Sarah M.; Kearney, Patrick C.; Mecozzi, Sandro; Russell, Keith; Dougherty, Dennis A.
Journal of the American Chemical Society, 1999 , vol. 121, # 6 p. 1192 - 1201
反应条件
1: 81 percent / dimethylformamide / 48 h / Heating
2: KOH / bis-(2-hydroxy-ethyl) ether / Heating
3: MeSO3H / 10 h / Heating
4: 42 percent / NBS, benzoyl peroxide / CCl4 / 21 h / Heating
View Scheme
参考文献
Ngola, Sarah M.; Kearney, Patrick C.; Mecozzi, Sandro; Russell, Keith; Dougherty, Dennis A.
Journal of the American Chemical Society, 1999 , vol. 121, # 6 p. 1192 - 1201
反应条件
1: CrO3
2: NaBH4
View Scheme
参考文献
Fan, Qu-Li; Lu, Su; Lai, Yee-Hing; Hou, Xiao-Yuan; Huang, Wei
Macromolecules, 2003 , vol. 36, # 19 p. 6976 - 6984
反应条件
in N,N-dimethyl-formamide
48 h; Heating;
参考文献
Ngola, Sarah M.; Kearney, Patrick C.; Mecozzi, Sandro; Russell, Keith; Dougherty, Dennis A.
Journal of the American Chemical Society, 1999 , vol. 121, # 6 p. 1192 - 1201
反应条件
in N,N-dimethyl-formamide
24 h; Reflux;
参考文献
Huang, Chibao; Qu, Junle; Qi, Jing; Yan, Meng; Xu, Gaixia
Organic Letters, 2011 , vol. 13, # 6 p. 1462 - 1465
