反应条件
Stage #1: <a href="#" onclick="return RXDsubstances(event, this, '4334696', constants.ctx, '0')">1,3-Dihydro-5-phenyl-3(R,S)-[(benzyloxycarbonyl)-amino]-2H-1,4-benzodiazepin-2-one</a> <b>With</b> <a href="#" onclick="return RXDsubstances(event, this, '4122952', constants.ctx, '0')">sodium hydride</a> <b>in</b> <a href="#" onclick="return RXDsubstances(event, this, '605365', constants.ctx, '0')">N,N-dimethyl-formamide</a> <br />T=0°C; 1.5 h; <br />Stage #2: <a href="#" onclick="return RXDsubstances(event, this, '969135', constants.ctx, '0')">methyl iodide</a> <b>in</b> <a href="#" onclick="return RXDsubstances(event, this, '605365', constants.ctx, '0')">N,N-dimethyl-formamide</a> <br />T=0°C; 1.5 h; <br />Stage #3: <b>With</b> <a href="#" onclick="return RXDsubstances(event, this, '11343360', constants.ctx, '0')">sodium hydrogen sulphate</a>; <a href="#" onclick="return RXDsubstances(event, this, '3587155', constants.ctx, '0')">water</a> <b>in</b> <a href="#" onclick="return RXDsubstances(event, this, '605365', constants.ctx, '0')">N,N-dimethyl-formamide</a> <br /> <br /> <br />
参考文献
UNIVERSITA' DEGLI STUDI DI FIRENZE; A.I.L. FIRENZE SEZIONE AUTONOMA DI FIRENZE DELL'ASSOCIAZIONE ITALIANA CONTRO LE LEUCEMIE, LINFOMI E MIELOMA - ONLUS Patent: WO2009/81349 A1, 2009 ; Location in patent: Page/Page column 20-21 ;
