6-(叔丁基二甲基甲硅烷基氧基)-吲哚合成路线 （共 6 条）
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene in tetrahydrofuran 4 h;
参考文献
WO2013/45516 A1, ;
Page/Page column 131; 183; 184 ;
反应条件
1: 73 percent / H2 / 10percent Pd/C / acetone / 16 h 2: 2,6-lutidine / CH2Cl2 / 0.37 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 37, # 13 p. 2011 - 2032
反应条件
1: 72 percent / BBr3 / CH2Cl2 / 15 h / 0 - 20 °C 2: diisopropylethylamine / dimethylformamide / 15 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 47, # 17 p. 4247 - 4257
反应条件
2,6-dimethylpyridine in dichloromethane 0.366667 h;
参考文献
Journal of Medicinal Chemistry, , vol. 37, # 13 p. 2011 - 2032
反应条件
N-chloro-succinimide in dichloromethane
T=0 - 20°C; 2.5 h;
参考文献
Ackermann, Jean; Aebi, Johannes; Binggeli, Alfred; Grether, Uwe; Hirth, Georges; Kuhn, Bernd; Maerki, Hans-Peter; Meyer, Markus; Mohr, Peter; Wright, Matthew Blake
Patent: US2005/4187 A1, 2005 ;
Location in patent: Page 22; 29; 30 ;
反应条件
1: 4-(N,N-dimethlyamino)pyridine; triethylamine / N,N-dimethyl-formamide / 1 h / 0 - 20 °C
2: tri-isopropoxy-borane; lithium diisopropyl amide / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere
View Scheme
参考文献
Herdemann, Matthias; Weber, Alexander; Jonveaux, Jerome; Schwoebel, Frank; Stoeck, Michael; Heit, Isabelle
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 6 p. 1852 - 1856
