(S)-5-(((叔丁基二甲基甲硅烷基)氧基)甲基)吡咯烷-2-酮合成路线 （共 12 条）
反应条件
1H-imidazole in N,N-dimethyl-formamide T=0°C; 12 h;
参考文献
Kurtz, Kimberly C. M.; Hsung, Richard P.; Zhang, Yanshi
Organic Letters, 2006 , vol. 8, # 2 p. 231 - 234
反应条件
1: NaBH4; EtOH / 12 h / 0 °C 2: 99 percent / imidazole / dimethylformamide / 20 h / 20 °C View Scheme
参考文献
Oliveira, Davi De Jesus; Coelho, Fernando
Synthetic Communications, 2000 , vol. 30, # 12 p. 2143 - 2159
反应条件
1: SOCl2 / 2 h / -15 °C 2: NaBH4; EtOH / 12 h / 0 °C 3: 99 percent / imidazole / dimethylformamide / 20 h / 20 °C View Scheme
参考文献
Oliveira, Davi De Jesus; Coelho, Fernando
Tetrahedron Letters, 2001 , vol. 42, # 39 p. 6793 - 6796
反应条件
sodium hydride in diethyl ether 16 h;
参考文献
Shimamoto, Keiko; Ishida, Michiko; Shinozaki, Haruhikio; Ohfune, Yasufumi
Journal of Organic Chemistry, 1991 , vol. 56, # 13 p. 4167 - 4176
反应条件
1: DCC / ethyl acetate / 1.) 0 deg C, 2.) 3 h, room temperature 2: NaBH4 / ethanol; tetrahydrofuran / 0.25 h / 0 °C 3: 92 percent / imidazole / dimethylformamide / 3 h / Ambient temperature 4: NaH / diethyl ether / 1.) 0 deg C, 2.) 18 h, room temperature View Scheme
参考文献
Shimamoto, Keiko; Ohfune, Yasufumi
Tetrahedron Letters, 1989 , vol. 30, # 29 p. 3803 - 3804
反应条件
1: 92 percent / imidazole / dimethylformamide / 3 h / Ambient temperature 2: NaH / diethyl ether / 1.) 0 deg C, 2.) 18 h, room temperature View Scheme
参考文献
Shimamoto, Keiko; Ohfune, Yasufumi
Tetrahedron Letters, 1989 , vol. 30, # 29 p. 3803 - 3804
反应条件
1: NaBH4 / ethanol; tetrahydrofuran / 0.25 h / 0 °C 2: 92 percent / imidazole / dimethylformamide / 3 h / Ambient temperature 3: NaH / diethyl ether / 1.) 0 deg C, 2.) 18 h, room temperature View Scheme
参考文献
Shimamoto, Keiko; Ohfune, Yasufumi
Tetrahedron Letters, 1989 , vol. 30, # 29 p. 3803 - 3804
反应条件
1: 92 percent / imidazole / dimethylformamide / 3 h / Ambient temperature 2: NaH / diethyl ether / 1.) 0 deg C, 2.) 18 h, room temperature View Scheme
参考文献
Shimamoto, Keiko; Ohfune, Yasufumi
Tetrahedron Letters, 1989 , vol. 30, # 29 p. 3803 - 3804
反应条件
1.1: water / 48 h / Heating 1.2: 90.1 percent / thionyl chloride / 48 h / 20 °C 2.1: 82.9 percent / sodium borohydride / ethanol / 3 h / 20 °C 3.1: 1.750 g / triethylamine / CH2Cl2 / 12 h / 20 °C View Scheme
参考文献
Saleh, Abdullah; D'Angelo, John G.; Morton, Martha D.; Quinn, Jesse; Redden, Kendra; Mielguz, Rafal W.; Pavlik, Christopher; Smith, Michael B.
Journal of Organic Chemistry, 2011 , vol. 76, # 14 p. 5574 - 5583
反应条件
1: sodium tetrahydroborate / ethanol 2: 1H-imidazole / N,N-dimethyl-formamide / 24 h / 20 °C View Scheme
参考文献
Saleh, Abdullah; D'Angelo, John G.; Morton, Martha D.; Quinn, Jesse; Redden, Kendra; Mielguz, Rafal W.; Pavlik, Christopher; Smith, Michael B.
Journal of Organic Chemistry, 2011 , vol. 76, # 14 p. 5574 - 5583
