4-溴氯苯合成路线

参考文献

BIOENERGENIX; MCCALL, John, M.; MCKEARN, John; ROMERO, Donnal, L.; CLAIR, Michael
Patent: WO2011/28947 A2, 2011 ;
WO 2011/028947 A1

106-39-84-溴氯苯

38944-14-82-(4-氯苯基)吡咯烷

参考文献

Elslager, Edward F.; Johnson, Judith L.; Werbel, Leslie M.
Journal of Medicinal Chemistry, 1981 , vol. 24, # 2 p. 140 - 145

106-39-84-溴氯苯

36938-76-84-(4-氯苄基)哌啶

参考文献

Ting, Pauline C.; Lee, Joe F.; Wu, Jie; Umland, Shelby P.; Aslanian, Robert; Cao, Jianhua; Dong, Youhao; Garlisi, Charles G.; Gilbert, Eric J.; Huang, Ying; Jakway, James; Kelly, Joseph; Liu, Zhidan; McCombie, Stuart; Shah, Himanshu; Tian, Fang; Wan, Yuntao; Shih, Neng-Yang
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 5 p. 1375 - 1378

106-39-84-溴氯苯+

107-19-72-丙炔-1-醇

37614-57-63-(4-氯苯基)-2-丙炔-1-醇

参考文献

Lin, Bo-Nan; Huang, Shao-Hsien; Wu, Wei-Yi; Mou, Chung-Yuan; Tsai, Fu-Yu
Molecules, 2010 , vol. 15, # 12 p. 9157 - 9173

参考文献

Shi, Lei; Chu, Yuanyuan; Knoechel, Paul; Mayr, Herbert
Journal of Organic Chemistry, 2009 , vol. 74, # 7 p. 2760 - 2764

参考文献

Neumann, R.; Sasson, Y.
Tetrahedron, 1983 , vol. 39, # 20 p. 3437 - 3440

106-39-84-溴氯苯+

340-07-81-三氟乙酰基哌啶

321-37-94'-氯-2,2,2-三氟苯乙酮

参考文献

Dong, Kaiwu; Li, Yang; Wang, Zheng; Ding, Kuiling
Angewandte Chemie - International Edition, 2013 , vol. 52, # 52 p. 14191 - 14195
Angew. Chem., 2013 , vol. 125, # 52 p. 14441 - 14445,5

106-39-84-溴氯苯+

76-05-1三氟乙酸

321-37-94'-氯-2,2,2-三氟苯乙酮

参考文献

Diderich,G.
Helvetica Chimica Acta, 1972 , vol. 55, p. 2103 - 2112

106-39-84-溴氯苯+

360-92-9N,N-二乙基-2,2,2-三氟乙酰胺

321-37-94'-氯-2,2,2-三氟苯乙酮

参考文献

Dneprovskii, A. S.; Eliseenkov, E. V.; Mil'tsov, S. A.
Journal of Organic Chemistry USSR (English Translation), 1982 , vol. 18, p. 317 - 324
Zhurnal Organicheskoi Khimii, 1982 , vol. 18, # 2 p. 365 - 373

106-39-84-溴氯苯+

407-25-0三氟乙酸酐

321-37-94'-氯-2,2,2-三氟苯乙酮

参考文献

Dice; Scheinman; Berrodin
Journal of medicinal chemistry, 1966 , vol. 9, # 2 p. 176 - 178