4-溴-2-氟苯腈合成路线

202865-64-34-溴-2-氟苯甲醛肟

→

105942-08-34-溴-2-氟苯腈

参考文献

WO2006/38100 A1, ;

Page/Page column 74 ;

367-24-84-溴-2-氟苯胺+

151-50-8氰化钾

→

105942-08-34-溴-2-氟苯腈

参考文献

Gray, G. W.; Hird, M.; Lacey, D.; Toyne, K. J.
Molecular Crystals and Liquid Crystals (1969-1991), 1989 , vol. 172, p. 165 - 190

348-54-92-氟苯胺

→

105942-08-34-溴-2-氟苯腈

参考文献

Molecular Crystals and Liquid Crystals (1969-1991), , vol. 172, p. 165 - 190

367-24-84-溴-2-氟苯胺+

544-92-3氰化亚铜

→

105942-08-34-溴-2-氟苯腈

参考文献

Journal of Organic Chemistry, , vol. 55, # 16 p. 4817 - 4821

67-56-1甲醇+

105942-08-34-溴-2-氟苯腈

→

330793-38-94-溴-2-甲氧基苯腈

参考文献

BAYER HEALTHCARE AG
Patent: WO2008/25509 A1, 2008 ;
Location in patent: Page/Page column 91-92 ;

105942-08-34-溴-2-氟苯腈

→

330793-38-94-溴-2-甲氧基苯腈

参考文献

BAYER PHARMACEUTICALS CORPORATION
Patent: WO2003/72561 A1, 2003 ;
Location in patent: Page/Page column 66-67 ;

124-41-4甲醇钠+

105942-08-34-溴-2-氟苯腈

→

330793-38-94-溴-2-甲氧基苯腈

参考文献

VERTEX PHARMACEUTICALS INCORPORATED?
Patent: WO2005/95400 A1, 2005 ;
Location in patent: Page/Page column 340-341 ;
WO 2005/095400 A1

865-33-8甲醇钾+

105942-08-34-溴-2-氟苯腈

→

330793-38-94-溴-2-甲氧基苯腈

参考文献

Abbott Laboratories
Patent: US6921763 B2, 2005 ;

67-56-1甲醇+

124-41-4甲醇钠+

105942-08-34-溴-2-氟苯腈

→

330793-38-94-溴-2-甲氧基苯腈

参考文献

WYETH
Patent: WO2009/108838 A1, 2009 ;
Location in patent: Page/Page column 86 ;
WO 2009/108838 A1

105942-08-34-溴-2-氟苯腈

→

404827-77-63-氨基-6-溴-1H-吲唑

参考文献

Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 14 p. 4579 - 4584