(2S)-3-[[(叔丁基)二甲基硅烷基]氧基]-2-甲基-1-丙醇合成路线 （共 14 条）
反应条件
TEA; diisobutylaluminium hydride; 4-(N,N-dimethlyamino)pyridine 2) CH2Cl2, -78 deg C; Multistep reaction;
参考文献
Kraft, Philip; Tochtermann, Werner
Liebigs Annalen der Chemie, 1994 , # 12 p. 1161 - 1164
反应条件
1: With (+)-(NMI)2ZrCl2 2: With oxygen Title compound not separated from byproducts;
参考文献
Liang, Bo; Novak, Tibor; Tan, Ze; Negishi, Ei-Ichi
Journal of the American Chemical Society, 2006 , vol. 128, # 9 p. 2770 - 2771
反应条件
N-methyl-2,2,6,6-tetramethylpiperidine; (2R,4S)-3-((R)-cyclopentyl(1-methyl-1H-imidazol-2-yl)methyl)-4-isopropyl-2-methoxyoxazolidine; Pempidine hydrochloride in tetrahydrofuran T=4°C; Inert atmosphere; Overall yield = 36 percent; Overall yield = 15 mg;
参考文献
Giustra, Zachary X.; Tan, Kian L.
Chemical Communications, 2013 , vol. 49, # 39 p. 4370 - 4372
反应条件
1: 93 percent / pyridine / 3.5 h / 0 °C 2: 96 percent / tetrahydrofuran / 12 h / -20 - 20 °C 3: KHDMS, 18-krown-6 / tetrahydrofuran / 1 h / -78 °C View Scheme
参考文献
Mulzer, Johann; Mantoulidis, Andreas; Oehler, Elisabeth
Tetrahedron Letters, 1998 , vol. 39, # 47 p. 8633 - 8636
