4-二乙氨基-2-丁炔-1-醇合成路线 （共 18 条）
反应条件
copper(II) sulfate in water T=80°C; Mannich reaction; pH=8.0; 2 h;
参考文献
Wang, San-yong; Mao, Wei-wei; She, Zhi-gang; Li, Chun-rong; Yang, Ding-qiao; Lin, Yong-cheng; Fu, Li-wu
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 10 p. 2785 - 2788
反应条件
sodium hydroxide T=100°C; 3 h;
参考文献
Farmaco, , vol. 60, # 8 p. 689 - 699
参考文献
Zhurnal Organicheskoi Khimii, , vol. 2, p. 802 - 803,805 - 806
反应条件
sulfuric acid Ambient temperature;
参考文献
J. Gen. Chem. USSR (Engl. Transl.), , vol. 41, p. 2227 - 2229,2253 - 2255
参考文献
Bulletin de la Societe Chimique de France, , p. 502
反应条件
ethylmagnesium bromide 1.) ether/CH2Cl2, 35 deg C; 2.) ether/CH2Cl2, 15 h, 20 deg C; Yield given. Multistep reaction;
参考文献
Bulletin de la Societe Chimique de France, , vol. 2, # 1-2 p. 21 - 27
参考文献
Zhurnal Organicheskoi Khimii, , vol. 3, # 11 p. 2012 - 2018,1962 - 1967
反应条件
Tris-HCl buffer; human liver carboxylesterase pI 4.5 T=37°C; Hydrolysis; pH=7.4; Enzyme kinetics;
参考文献
Biological and Pharmaceutical Bulletin, , vol. 20, # 8 p. 869 - 873
反应条件
1: With 4-methyl-morpholine; benzotriazol-1-ol in dichloromethane T=0°C; 1 h; 2: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in dichloromethane T=0 - 20°C; 16 h;
参考文献
AUSPEX PHARMACEUTICALS, INC.
Patent: US2009/247628 A1, 2009 ;
Location in patent: Page/Page column 53-54 ;
US 20090247628 A1
反应条件
manganese(IV) oxide; potassium hydroxide in benzene
参考文献
Vereshchagin,L.I. et al.
Zhurnal Organicheskoi Khimii, 1976 , vol. 12, p. 1165 - 1169,1174 - 1178
