1-(异氰基甲基磺酰基)-4-甲基苯合成路线 （共 7 条）
反应条件
dimethyl sulfoxide; trifluoroacetic anhydride in dichloromethane T=-78 - 20°C; 0.166667 h; Inert atmosphere;
参考文献
Le, Hoang V.; Ganem, Bruce
Tetrahedron Letters, 2014 , vol. 55, # 12 p. 2003 - 2005
反应条件
potassium carbonate in methanol; water
参考文献
Liu, Chunjian; Dhar, T.G. Murali; Gu, Henry H.; Iwanowicz, Edwin J.; Leftheris, Katerina; Pitts, William J.; Herpin, Timothy F.; Pi, Zulan; Bisacchi, Gregory S.
Patent: US2002/143176 A1, 2002 ;
反应条件
potassium carbonate in methanol 2 h; Heating;
参考文献
Hardouin, Christophe; Kelso, Michael J.; Romero, F. Anthony; Rayl, Thomas J.; Leung, Donmienne; Hwang, Inkyu; Cravatt, Benjamin F.; Boger, Dale L.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 14 p. 3359 - 3368
反应条件
1: diethoxyphosphoryl-acetic acid ethyl ester; benzaldehyde With potassium tert-butylate in tetrahydrofuran 2 h; 2: tosylmethylisocyanate With potassium tert-butylate in tetrahydrofuran 3 h;
参考文献
WO2007/58504 A1, ;
Page/Page column 53 ;
反应条件
potassium carbonate in methanol 2 h; Heating / reflux;
参考文献
F2G LTD
Patent: WO2006/123145 A1, 2006 ;
Location in patent: Page/Page column 66 ;
反应条件
potassium tert-butylate 1) DME, t-BuOH, 1,5 h, 2) DME, r.t., overnight; Yield given. Multistep reaction;
参考文献
Froehlich, Hannes; Gmeiner, Guenter; Sauter, Fritz
Journal fuer Praktische Chemie (Leipzig), 1990 , vol. 332, # 6 p. 995 - 1003
反应条件
1: With potassium tert-butylate in tetrahydrofuran; ethylene glycol dimethyl ether T=0 - 20°C; 5 h; 2: With water in tetrahydrofuran; ethylene glycol dimethyl ether T=0°C;
参考文献
ASTRAZENECA AB
Patent: WO2008/18827 A1, 2008 ;
Location in patent: Page/Page column 55 ;
WO 2008/018827 A1
