2-甲氧基-4-吡啶甲酸合成路线 （共 12 条）
反应条件
hydrogen; triethylamine; palladium 10 on activated carbon in methanol T=20°C; P=155.149 Torr;
参考文献
ALMIRALL, S.A.; GRIMA POVEDA, Pedro Manuel; AGUILAR IZQUIERDO, Nuria; MIR CEPEDA, Marta; LOPEZ MARTINEZ, Manuel
Patent: WO2010/43377 A1, 2010 ;
Location in patent: Page/Page column 64 ;
WO 2010/043377 A1
参考文献
Helvetica Chimica Acta, , vol. 38, p. 1046,1058
反应条件
2: palladium/charcoal; aqueous methanol; potassium acetate / Hydrogenation 3: aqueous methanol. KOH View Scheme
参考文献
Helvetica Chimica Acta, , vol. 38, p. 1046,1058
反应条件
1: palladium/charcoal; aqueous methanol; potassium acetate / Hydrogenation 2: aqueous methanol. KOH View Scheme
参考文献
Helvetica Chimica Acta, , vol. 38, p. 1046,1058
反应条件
1: 120 - 130 °C 2: concentrated H2SO4 3: palladium; aqueous methanol. KOH / Hydrogenation View Scheme
参考文献
Yakugaku Zasshi, , vol. 73, p. 845,846, 847
Chem.Abstr., , p. 10021
反应条件
potassium hydroxide; palladium Hydrogenation;
参考文献
Yakugaku Zasshi, , vol. 73, p. 845,846, 847
Chem.Abstr., , p. 10021
反应条件
1: HBr; acetic acid / H2O / 22 h / 80 °C 2: 96 mg / H2SO4 / 6 h / 80 °C View Scheme
参考文献
Kuramochi, Takahiro; Kakefuda, Akio; Yamada, Hiroyoshi; Tsukamoto, Issei; Taguchi, Taku; Sakamoto, Shuichi
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 12 p. 4022 - 4036
反应条件
1: 2-methoxypyridine-4-carboxylic acid With 4-methyl-morpholine in tetrahydrofuran T=0°C; 2: With isobutyl chloroformate in tetrahydrofuran T=20°C; 6 h; 3: aniline in tetrahydrofuran T=20°C; 16 h;
参考文献
Dales, Natalie; Fonarev, Julia; Fu, Jianmin; Hou, Duanjie; Kamboj, Rajender; Kodumuru, Vishnumurthy; Pokrovskaia, Natalia; Raina, Vandna; Sun, Shaoyi; Zhang, Zaihui
Patent: US2009/156615 A1, 2009 ;
Location in patent: Page/Page column 19 ;
US 20090156615 A1
参考文献
Okajima; Seki
Yakugaku Zasshi, 1953 , vol. 73, p. 845,846, 847
Chem.Abstr., 1954 , p. 10021
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran; diethyl ether T=20°C; 2: With water; sodium hydroxide in tetrahydrofuran; diethyl ether T=0°C; 1 h; Product distribution / selectivity;
参考文献
MERCK SHARP and DOHME CORP.; KUDUK, Scott, D.; SCHLEGEL, Kelly-Ann; YANG, Zhi-Qiang
Patent: WO2011/84368 A1, 2011 ;
Location in patent: Page/Page column 57-58 ;
WO 2011/084368 A1
