(2R, 3S)-(-)-对甲氧苯基缩水甘油酸甲酯合成路线 （共 38 条）
反应条件
lipase type VII in cyclohexane T=33°C; 9.5 h; Enzymatic reaction;
参考文献
Zambon Group S.p.A.
Patent: US6346632 B1, 2002 ;
Location in patent: Page column 7 ;
反应条件
lipase AMANO 9 h; Enzymatic reaction;
参考文献
Zambon Group S.p.A.
Patent: US6346632 B1, 2002 ;
Location in patent: Page column 5 ;
反应条件
1: 1-[(2E)-3-(4-methoxyphenyl)-1-oxo-2-propenyl]-4-phenyl-1H-imidazole With tert.-butylhydroperoxide; La-(S)-BINOL-Ph3AsO; 4 A molecular sieve in tetrahydrofuran; toluene T=20°C; 5 h; 2: methanol in tetrahydrofuran; toluene T=20°C; Title compound not separated from byproducts;
参考文献
Tetrahedron, , vol. 59, # 52 p. 10485 - 10497
反应条件
lipase type VII in hexane T=25°C; 26 h; Enzymatic reaction;
参考文献
US6346632 B1, ;
Page column 3-4 ;
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene in dichloromethane T=20°C; 2 h;
参考文献
Genet, Jean-Pierre; Cano De Andrade; Ratovelomanana-Vidal
Tetrahedron Letters, 1995 , vol. 36, # 12 p. 2063 - 2066
反应条件
1.1: 1-ethyl-3-(dimethylaminopropyl)carbodiimide hydrochloride / dimethylformamide / 12 h / 20 °C 2.1: La-(S)-BINOL-Ph3AsO complex; 4 Angstroem molecular sieves; tert-butyl hydroperoxide / toluene; tetrahydrofuran / 5 h / 20 °C 2.2: tetrahydrofuran; toluene / 20 °C View Scheme
参考文献
Tetrahedron, , vol. 59, # 52 p. 10485 - 10497
反应条件
lipase type VII in hexane; butanone T=24°C; 0.5 h; Enzymatic reaction;
参考文献
US6346632 B1, ;
Page column 6 ;
反应条件
lipase AMANO in hexane T=32°C; 4.5 h; Enzymatic reaction;
参考文献
US6346632 B1, ;
Page column 5 ;
反应条件
potassium carbonate in methanol; diethyl ether T=0 - 5°C; 0.5 h; Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Inoue; Matsuki; Oh-Ishi
Chemical and Pharmaceutical Bulletin, 1993 , vol. 41, # 9 p. 1521 - 1523
反应条件
n-butyllithium in diethyl ether; hexane T=-78°C; Inert atmosphere;
参考文献
Hajra, Saumen; Bhowmick, Manishabrata
Tetrahedron Asymmetry, 2010 , vol. 21, # 18 p. 2223 - 2229
