1,3-丙酮二羧酸二乙酯合成路线 （共 169 条）
反应条件
1: water / 1 h / 15 - 40 °C 2: sodium hydroxide / water / 3 h / 100 °C View Scheme
参考文献
Manoni, Francesco; Connon, Stephen J.
Angewandte Chemie - International Edition, 2014 , vol. 53, # 10 p. 2628 - 2632
Angew. Chem., 2014 , vol. 126, # 10 p. 2666 - 2670,5
反应条件
1.1: acetic anhydride / 1.5 h / 120 °C 1.2: 0 °C / Cooling 1.3: pH < 5 2.1: trichlorophosphate / 3 h / 110 °C 3.1: acetonitrile; water / 3.5 h / 0 - 20 °C 4.1: lithium aluminium tetrahydride / tetrahydrofuran / -78 °C 4.2: 20 °C 5.1: manganese(IV) oxide / dichloromethane / 20 °C View Scheme
参考文献
WO2011/97526 A1, ;
WO 2011/097526 A1
反应条件
1: hydrogenchloride; water 2: ammonia / water 3: thionyl chloride View Scheme
参考文献
Ong, Wei Qiang; Zhao, Huaiqing; Fang, Xiao; Woen, Susanto; Zhou, Feng; Yap, Weiliang; Su, Haibin; Li, Sam F. Y.; Zeng, Huaqiang
Organic Letters, 2011 , vol. 13, # 12 p. 3194 - 3197
反应条件
sodium carbonate; benzoic acid hydrazide in ethanol 21 h; Heating;
参考文献
Heterocycles, , vol. 35, # 1 p. 315 - 323
反应条件
sodium ethanolate in ethanol Ambient temperature;
参考文献
Farmaco, , vol. 53, # 4 p. 305 - 311
参考文献
v. Braun
Chemische Berichte, 1913 , vol. 46, p. 1792
Chemische Berichte, 1914 , vol. 47, p. 490
反应条件
1: concentrated aqueous HCl / anschliessend Erwaermen mit Acetessigsaeure-benzylester, Zink-Pulver, Essigsaeure und Ammoniumacetat 2: Raney nickel; ethanol / 100 °C / 73550.8 Torr / Hydrogenation 3: glycerol / 230 °C 4: aqueous NaOH 5: resorcinol View Scheme
参考文献
MacDonald
Journal of the Chemical Society, 1952 , p. 4176,4182
反应条件
zinc(II) chloride in ethanol Von Pechmann reaction; 15 h; Reflux;
参考文献
Song, Hong Y.; Ngai, Mun H.; Song, Zhen Y.; MacAry, Paul A.; Hobley, Jonathan; Lear, Martin J.
Organic and Biomolecular Chemistry, 2009 , vol. 7, # 17 p. 3400 - 3406
反应条件
in ethanol 2 h; Reflux;
参考文献
Bianchini, Roberto; Bonanni, Marco; Corsi, Massimo; Infantino, Angela Simona
Tetrahedron, 2012 , vol. 68, # 41 p. 8636 - 8644
反应条件
ethanol; sodium ethanolate
参考文献
Prelog; Metzler; Jeger
Helvetica Chimica Acta, 1947 , vol. 30, p. 675,683
