5-甲氧基-3-羰基-戊酸乙酯合成路线 （共 2 条）
反应条件
1: malonic acid ethyl ester monopotassium salt With magnesium chloride hydrate; triethylamine in acetonitrile T=20°C; 1 h; Inert atmosphere; 2: β-methoxypropionic acid With 1,1'-carbonyldiimidazole in acetonitrile 16 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED; BENGTSSON, Boel, Ase; BLACKABY, Wesley; CUMMING, John; FAULL, Alan, Wellington; LARSSON, Joakim; NASH, Ian, Alun; OLDHAM, Keith; PAPE, Andrew
Patent: WO2011/114148 A1, 2011 ;
Location in patent: Page/Page column 93 ;
WO 2011/114148 A1
反应条件
hydrogenchloride; Zn/Cu in tetrahydrofuran
参考文献
Cytopharm, Inc.
Patent: US5179120 A1, 1993 ;
