1-甲基吡咯烷-2-硫酮合成路线 （共 20 条）
参考文献
Singh, Harjit; Batra, Manohar S.; Singh, Paramjit
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1985 , vol. 24, p. 131 - 136
参考文献
Singh, Harjit; Batra, Manohar S.; Singh, Paramjit
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1985 , vol. 24, p. 131 - 136
反应条件
1: diethyl ether
2: EtN3, Ph3P / acetonitrile / 2 h / Ambient temperature
3: 93 percent / lithium aluminium hydride / diethyl ether / 0.5 h / Ambient temperature
View Scheme
参考文献
Ghirlando, Rodolfo; Howard, Arthur S.; Katz, Ruth B.; Michael, Joseph P.
Tetrahedron, 1984 , vol. 40, # 15 p. 2879 - 2884
参考文献
Michael, Joseph P.; Howard, Arthur S.; Katz, Ruth B.; Zwane, Mzwandile I,
Tetrahedron Letters, 1992 , vol. 33, # 33 p. 4751 - 4754
反应条件
1: diethyl ether
2: EtN3 / acetonitrile / 2 h / Ambient temperature
3: 92 percent / lithium aluminium hydride / CH2Cl2 / 0.5 h / Ambient temperature
View Scheme
参考文献
Ghirlando, Rodolfo; Howard, Arthur S.; Katz, Ruth B.; Michael, Joseph P.
Tetrahedron, 1984 , vol. 40, # 15 p. 2879 - 2884
反应条件
1: tetrahydrofuran / 1 h / 0 °C
2: Et3N / CH2Cl2 / 72 h / 20 °C
View Scheme
参考文献
Michael, Joseph P.; De Koning, Charles R.; Malefetse, Tshepo J.; Yillah, Ibrahim
Organic and Biomolecular Chemistry, 2004 , vol. 2, # 23 p. 3510 - 3517
反应条件
1: tetrahydrofuran / 6 h / Ambient temperature
2: 1) BuLi / 1) hexane, THF, 2) THF, -78 deg C
3: 1) LiAlH4, 2) 10percent aq. NaOH / 1) -20 deg C, 2 h, THF, hexane, 2) -10 deg C, 1 h, THF, hexane
View Scheme
参考文献
Takahata, Hiroki; Takahashi, Koichi; Wang, Eng-Chi; Yamazaki, Takao
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1989 , p. 1211 - 1214
反应条件
1: tetrahydrofuran / 1 h / 0 °C
2: Et3N / CH2Cl2 / 72 h / 20 °C
3: 86 percent / sodium amalgam; Na2HPO4 / tetrahydrofuran; methanol / 14 h
View Scheme
参考文献
Michael, Joseph P.; De Koning, Charles R.; Malefetse, Tshepo J.; Yillah, Ibrahim
Organic and Biomolecular Chemistry, 2004 , vol. 2, # 23 p. 3510 - 3517
反应条件
silver carbonate in acetonitrile
T=25°C; 1 h; other active methylene compounds, other thioamides;
参考文献
Brillon, Denis; Sauve, Gilles
Journal of Organic Chemistry, 1990 , vol. 55, # 7 p. 2246 - 2249
反应条件
1: 90 percent / CH2Cl2 / 0.5 h / Ambient temperature
2: 90 percent / KF / Triethylbenzylammonium chloride / CH2Cl2 / 6 h / Ambient temperature
View Scheme
参考文献
Singh, Harjit; Batra, M. S.; Singh, Paramjit
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1984 , vol. 23, # 12 p. 1176 - 1180
