5-溴-1H-吲哚-3-甲酸合成路线 （共 6 条）
反应条件
1: With sodium hydroxide in water 2.5 h; Reflux; 2: With hydrogenchloride in water pH=1;
参考文献
UNIVERSITE JOSEPH FOURIER; DENIS, Jean-Noël; JOLIVALT, Claude, Marcelle; MAURIN, Max, Maurin, Louis; JEANTY, Matthieu
Patent: WO2013/14102 A1, 2013 ;
Location in patent: Page/Page column 26; 30; 31 ;
反应条件
1: With lithium tert-butylate in N,N-dimethyl-formamide T=100°C; P=760.051 Torr; 24 h; 2: With hydrogenchloride in water; N,N-dimethyl-formamide
参考文献
Yoo, Woo-Jin; Capdevila, Montse Guiteras; Du, Xiangwei; Kobayashi, Shu
Organic Letters, 2012 , vol. 14, # 20 p. 5326 - 5329,4
反应条件
1.1: diethyl ether / -5 °C 2.1: potassium hydroxide; water / 4 h / Reflux 2.2: 5 °C / Aqueous phosphate buffer View Scheme
参考文献
US2012/277205 A1, ;
US 20120277205 A1
反应条件
sulfuric acid in ethanol Reflux;
参考文献
Kumar, Dalip; Maruthi Kumar; Ghosh, Soumitra; Shah, Kavita
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 1 p. 212 - 215
反应条件
sulfuric acid 20 h; Reflux;
参考文献
Tantak, Mukund P; Kumar, Anil; Noel, Brett; Shah, Kavita; Kumar, Dalip
ChemMedChem, 2013 , vol. 8, # 9 p. 1468 - 1474
反应条件
copper(l) chloride in 1-methyl-pyrrolidin-2-one T=205 - 210°C; 15 h;
参考文献
Keetha, Laxminarayana; Palle, Sadanandam; Ramanatham, Vinodkumar; Khagga, Mukkanti; Chinnapillai, Rajendiran
Journal of the Korean Chemical Society, 2011 , vol. 55, # 2 p. 240 - 242
