2-环己基-2-羟基苯乙酸甲酯合成路线 （共 21 条）
反应条件
1: 1-bromocyclohexane With cyclohexyl monochloride; iodine; magnesium in tetrahydrofuran T=25 - 75°C; 2.5 h; 2: benzoyl-formic acid methyl ester in tetrahydrofuran T=6 - 14°C; 2 h; 3: With hydrogenchloride in water; toluene T=5 - 38°C;
参考文献
EP1205464 A2, ;
Page 15 ;
反应条件
hydrogen; palladium on activated charcoal in methanol P=2625.26 Torr; 10 h;
参考文献
EP1205464 A2, ;
Example 9 ;
反应条件
palladium monocarbide in methanol; hydrogen; cyclohexene
反应条件
hydrogenchloride; iodine; magnesium in tetrahydrofuran; toluene
反应条件
lithium diisopropyl amide in tetrahydrofuran T=-78 - 20°C;
参考文献
Tetrahedron, , vol. 57, # 6 p. 1075 - 1081
反应条件
1: H2, glacial AcOH / PtO2 / 28 h / 80 °C / 3102.9 Torr 2: NaHCO3 / dimethylformamide / 24 h / Ambient temperature View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 46, # 2 p. 231 - 241
反应条件
sodium hydrogencarbonate in N,N-dimethyl-formamide 24 h; Ambient temperature;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 46, # 2 p. 231 - 241
反应条件
acetic acid; platinum Hydrogenation;
参考文献
Journal of Organic Chemistry, , vol. 24, p. 1301,1305
参考文献
Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 40, p. 515 - 517
反应条件
lithium diisopropyl amide
参考文献
Tetrahedron Letters, , vol. 39, # 20 p. 3327 - 3330
