反应条件
1: With (S)-(-)-α,α-bis[3,5-(trifluoromethyl)phenyl]-2-pyrrolidinemethanol in tetrahydrofuran
T=4°C; Mannich asymmetric reaction; 48 h; Sealed tube;
2: With lithium aluminium tetrahydride in tetrahydrofuran
T=-50°C; 1 h;
参考文献
Hayashi, Yujiro; Okano, Tsubasa; Itoh, Takahiko; Urushima, Tatsuya; Ishikawa, Hayato; Uchimaru, Tadafumi
Angewandte Chemie - International Edition, 2008 , vol. 47, # 47 p. 9053 - 9058
