4'-(三氟甲基)-4-联苯醇合成路线 （共 10 条）
反应条件
potassium carbonate; palladium diacetate in water T=20°C; In open air; Product distribution / selectivity;
参考文献
ELI LILLY AND COMPANY
Patent: WO2005/123668 A1, 2005 ;
Location in patent: Page/Page column 44 ;
WO 2005/123668 A1
反应条件
sodium carbonate; tetrakis(triphenylphosphine) palladium(0) in ethylene glycol dimethyl ether; water T=95°C; Suzuki reaction;
参考文献
Edsall Jr., Richard J; Harris, Heather A; Manas, Eric S; Mewshaw, Richard E
Bioorganic and medicinal chemistry, 2003 , vol. 11, # 16 p. 3457 - 3474
反应条件
trimethylsilyl iodide in chloroform T=20°C; 120 h;
参考文献
Barny, P. le; Ravaux, G.; Dubois, J. C.; Parneix, J. P.
Molecular Crystals and Liquid Crystals (1969-1991), 1985 , vol. 127, p. 413 - 430
反应条件
NaH-t-AmONa-Ni(OAc)2-bpy-KI in tetrahydrofuran; benzene T=63°C; 0.75 h; Yields of byproduct given;
参考文献
Lourak, Mouhsine; Vanderesse, Regis; Fort, Yves; Caubere, Paul
Journal of Organic Chemistry, 1989 , vol. 54, # 20 p. 4844 - 4848
反应条件
tetrakis(triphenylphosphine) palladium(0); K3PO4*3H2O in water; N,N-dimethyl-formamide T=100°C; Suzuki coupling; 18 h; Inert atmosphere;
参考文献
Ran, Yan; Ma, Liang; Wang, Xuewei; Chen, Jinying; Wang, Guangcheng; Peng, Aihua; Chen, Lijuan
Molecules, 2012 , vol. 17, # 7 p. 8091 - 8104
反应条件
1.1: 100 percent / imidazole / dimethylformamide / 20 °C 2.1: n-butyl lithium / tetrahydrofuran / 0.5 h / -78 °C 2.2: triisopropyl borate / tetrahydrofuran / -78 - 20 °C 2.3: 65 percent / HCl / tetrahydrofuran; H2O / 0.08 h / 0 °C 3.1: 63 percent / Na2CO3 / Pd(PPh3)4 / 1,2-dimethoxy-ethane; H2O / 95 °C View Scheme
参考文献
Ran, Yan; Ma, Liang; Wang, Xuewei; Chen, Jinying; Wang, Guangcheng; Peng, Aihua; Chen, Lijuan
Molecules, 2012 , vol. 17, # 7 p. 8091 - 8104
反应条件
1.1: n-butyl lithium / tetrahydrofuran / 0.5 h / -78 °C 1.2: triisopropyl borate / tetrahydrofuran / -78 - 20 °C 1.3: 65 percent / HCl / tetrahydrofuran; H2O / 0.08 h / 0 °C 2.1: 63 percent / Na2CO3 / Pd(PPh3)4 / 1,2-dimethoxy-ethane; H2O / 95 °C View Scheme
参考文献
Edsall Jr., Richard J; Harris, Heather A; Manas, Eric S; Mewshaw, Richard E
Bioorganic and medicinal chemistry, 2003 , vol. 11, # 16 p. 3457 - 3474
反应条件
1: aq. NaOH / benzene 2: Cl2, (PhCO)2O2, urotropine / CCl4 3: SbF3 / Heating View Scheme
参考文献
Kozachuk,D.N. et al.
Journal of Organic Chemistry USSR (English Translation), 1971 , vol. 7, p. 1976 - 1981
Zhurnal Organicheskoi Khimii, 1971 , vol. 7, # 9 p. 1906 - 1911
反应条件
1: 87 percent / NaOEt / ethanol 2: 40 percent / copper powder / dimethylformamide / 20 h / 150 °C / in autoclave 3: 79 percent / (CH3)3SiI / CHCl3 / 120 h / 20 °C View Scheme
参考文献
Barny, P. le; Ravaux, G.; Dubois, J. C.; Parneix, J. P.
Molecular Crystals and Liquid Crystals (1969-1991), 1985 , vol. 127, p. 413 - 430
反应条件
1: 40 percent / copper powder / dimethylformamide / 20 h / 150 °C / in autoclave 2: 79 percent / (CH3)3SiI / CHCl3 / 120 h / 20 °C View Scheme
参考文献
Barny, P. le; Ravaux, G.; Dubois, J. C.; Parneix, J. P.
Molecular Crystals and Liquid Crystals (1969-1991), 1985 , vol. 127, p. 413 - 430
