5,6-二氢-[1,1’-联苯]-3(4H)-酮合成路线 （共 31 条）
反应条件
1: nBuLi, cyclohexyl-isopropyl-amine / tetrahydrofuran
2: Pd-C / 260 °C
3: LiAlH4 / diethyl ether
View Scheme
参考文献
Lyle,T.L.; Daub,G.H.
Journal of Organic Chemistry, 1979 , vol. 44, # 26 p. 4933 - 4938
参考文献
Hong, Wan Pyo; Iosub, Andrei V.; Stahl, Shannon S.
Journal of the American Chemical Society, 2013 , vol. 135, # 37 p. 13664 - 13667
反应条件
diethyl ether; benzene
Erhitzen des Reaktionsprodukts mit Palladium/Kohle auf 280grad bis 310grad;
参考文献
Alexander
Journal of Organic Chemistry, 1956 , vol. 21, p. 1464
反应条件
(i), (ii) H2SO4, (iii) Br2; Multistep reaction;
参考文献
Woods,G.F. et al.
Journal of the American Chemical Society, 1960 , vol. 82, p. 5227 - 5232
反应条件
N-Trimethylamine hydrochloride in water; N,N-dimethyl-formamide
T=90°C; 6 h;
参考文献
Johnson, James A.; Lloyd, John; Kover, Alexander
Patent: US2005/250783 A1, 2005 ;
Location in patent: Page/Page column 32 ;
反应条件
triethyl amine hydrochloride in N,N-dimethyl-formamide
参考文献
Wu, Yong-Jin; He, Huan
Patent: US2006/19944 A1, 2006 ;
Location in patent: Page/Page column 13 ;
US 20060019944 A1
反应条件
N-Trimethylamine hydrochloride in water; N,N-dimethyl-formamide
T=93°C; Michael Addition; 6 h;
参考文献
Wu, Yong-Jin; He, Huan; Bertekap, Robert; Westphal, Ryan; Lelas, Snjezana; Newton, Amy; Wallace, Tanya; Taber, Matthew; Davis, Carl; MacOr, John E.; Bronson, Joanne
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 8 p. 2217 - 2228
反应条件
potassium hydroxide; [bis(acetoxy)iodo]benzene in methanol
0.5 h; Ambient temperature;
参考文献
Tamura, Yasumitsu; Yakura, Takayuki; Terashi, Hiroaki; Haruta, Jun-Ichi; Kita, Yasuyuki
Chemical & Pharmaceutical Bulletin, 1987 , vol. 35, # 2 p. 570 - 577
反应条件
potassium hydroxide; [bis(acetoxy)iodo]benzene
0.5 h; Ambient temperature;
参考文献
Tamura, Yasumitsu; Yakura, Takayuki; Terashi, Hiroaki; Haruta, Jun-Ichi; Kita, Yasuyuki
Chemical & Pharmaceutical Bulletin, 1987 , vol. 35, # 2 p. 570 - 577
反应条件
Behandeln des Reaktionsprodukts mit Wasser;
参考文献
Abdullah
Journal of the Indian Chemical Society, 1935 , vol. 12, p. 64
Chem. Zentralbl., 1935 , vol. 106, # I p. 3926
