5,6-二氢-[1,1’-联苯]-3(4H)-酮合成路线 （共 31 条）
反应条件
diethyl-1,4-dihydro-2,6-dimethyl-3,5-pyridine dicarboxylate; valine tert-butyl ester (R)-TRIP salt in anhydrous butyl ether T=60°C; 48 h; Title compound not separated from byproducts;
参考文献
Scheuermann Nee Taylor, Caroline J.; Jaekel, Christoph
Advanced Synthesis and Catalysis, 2008 , vol. 350, # 17 p. 2708 - 2714
反应条件
1: With {(S)-1-[(R)-(diphenylphosphino)ferrocenyl]}ethyl-di-tert-butylphosphine; methyl-diethoxy-silane; copper (II) acetate monohydrate in diethyl ether T=-25°C; 24 h; Inert atmosphere; 2: With ammonium fluoride in methanol; diethyl ether T=-25°C; Inert atmosphere; regioselective reaction;
参考文献
Voigtritter, Karl R.; Isley, Nicholas A.; Moser, Ralph; Aue, Donald H.; Lipshutz, Bruce H.
Tetrahedron, 2012 , vol. 68, # 17 p. 3410 - 3416
反应条件
nickel T=180 - 190°C; P=84583.4 Torr; Hydrogenation;
参考文献
Ssidorowa; Iwanowa
Zhurnal Obshchei Khimii, 1962 , vol. 32, p. 2790
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Musser; Adkins
Journal of the American Chemical Society, 1938 , vol. 60, p. 664,666
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Sidorowa; Iwanowa
J. Gen. Chem. USSR (Engl. Transl.), 1962 , vol. 32, p. 2790,2747
反应条件
methyl-magnesium iodide; diethyl ether Erhitzen des nach der Hydrolyse erhaltenen Reaktionsprodukts mit Schwefel auf 220grad;
参考文献
Downes et al.
Journal of the American Chemical Society, 1950 , vol. 72, p. 3464,3466
反应条件
diethyl ether Kochen des nach der Hydrolyse erhaltenen Reaktionsprodukts mit Palladium-Kohle;
参考文献
Woods et al.
Journal of the American Chemical Society, 1949 , vol. 71, p. 2028
反应条件
Kochen des nach der Hydrolyse erhaltenen Reaktionsprodukts mit Palladium/Kohle;
参考文献
Woods et al.
Journal of the American Chemical Society, 1949 , vol. 71, p. 2028
反应条件
palladium 10 on activated carbon; hydrogen in merthanol P=1500.15 Torr;
参考文献
Verendel, J. Johan; Li, Jia-Qi; Quan, Xu; Peters, Byron; Zhou, Taigang; Gautun, Odd R.; Govender, Thavendran; Andersson, Pher G.
Chemistry - A European Journal, 2012 , vol. 18, # 21 p. 6507 - 6513
反应条件
T=20°C; Hydrogenation;
参考文献
Woods; Tucker
Journal of the American Chemical Society, 1948 , vol. 70, p. 2174,2176
反应条件
hydrogen bromide; oxygen; copper(ll) bromide in 1,4-dioxane; water T=20°C; 20 h; Sealed tube; Time;
参考文献
Kikushima, Kotaro; Nishina, Yuta
RSC Advances, 2013 , vol. 3, # 43 p. 20150 - 20156
反应条件
bromine in 1,4-dioxane T=20°C; 20 h;
参考文献
RSC Advances, , vol. 3, # 43 p. 20150 - 20156
