4-氰基 2-甲基苯甲酸甲酯合成路线 （共 10 条）
反应条件
tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide T=100°C; 16 h; Inert atmosphere;
参考文献
SYNGENTA PARTICIPATIONS AG; JUNG, Pierre Joseph Marcel; GODFREY, Christopher Richard Ayles; HUETER, Ottmar Franz; MAIENFISCH, Peter
Patent: WO2010/127926 A1, 2010 ;
Location in patent: Page/Page column 46 ;
反应条件
tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide T=100°C; 2 h;
参考文献
EXELIXIS, INC.
Patent: WO2009/55077 A1, 2009 ;
Location in patent: Page/Page column 430 ;
反应条件
tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide T=100°C; 16 h; Inert atmosphere;
参考文献
SYNGENTA PARTICIPATIONS AG
Patent: WO2009/77197 A1, 2009 ;
Location in patent: Page/Page column 35 ;
反应条件
T=180°C; 5 h; Inert atmosphere;
参考文献
F. HOFFMANN-LA ROCHE AG; AEBI, Johannes; AMREIN, Kurt; CHEN, Wenming; HORNSPERGER, Benoit; KUHN, Bernd; LIU, Yongfu; MAERKI, Hans P.; MAYWEG, Alexander V.; MOHR, Peter; TAN, Xuefei; WANG, Zhanguo; ZHOU, Mingwei
Patent: WO2013/79452 A1, 2013 ;
Location in patent: Page/Page column 165 ;
反应条件
in 1-methyl-pyrrolidin-2-one T=180°C; 5 h;
参考文献
PainCeptor Pharma Corporation
Patent: US2009/82368 A1, 2009 ;
Location in patent: Page/Page column 41-42 ;
反应条件
1: thionyl chloride / 6 h / 70 °C 2: N,N-dimethyl-formamide / 8 h / Reflux View Scheme
参考文献
F. HOFFMANN-LA ROCHE AG; AEBI, Johannes; AMREIN, Kurt; CHEN, Wenming; HORNSPERGER, Benoit; KUHN, Bernd; LIU, Yongfu; MAERKI, Hans P.; MAYWEG, Alexander V.; MOHR, Peter; TAN, Xuefei; WANG, Zhanguo; ZHOU, Mingwei
Patent: WO2013/79452 A1, 2013 ;
参考文献
Peltier
Bulletin de la Societe Scientifique de Bretagne, 1956 , vol. 31, p. Sonderheft S.9,41
反应条件
water; sodium hydroxide in ethanol T=20°C; 12 h;
参考文献
Sun, Xicheng; Qiu, Jian; Strong, Sarah A.; Green, Louis S.; Wasley, Jan W.F.; Colagiovanni, Dorothy B.; Mutka, Sarah C.; Blonder, Joan P.; Stout, Adam M.; Richards, Jane P.; Chun, Lawrence; Rosenthal, Gary J.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 12 p. 3671 - 3675
反应条件
N-bromosuccinmide; dibenzoyl peroxide in tetrachloromethane
参考文献
F. HOFFMANN-LA ROCHE AG; AEBI, Johannes; AMREIN, Kurt; CHEN, Wenming; HORNSPERGER, Benoit; KUHN, Bernd; LIU, Yongfu; MAERKI, Hans P.; MAYWEG, Alexander V.; MOHR, Peter; TAN, Xuefei; WANG, Zhanguo; ZHOU, Mingwei
Patent: WO2013/79452 A1, 2013 ;
Location in patent: Page/Page column 165 ;
反应条件
formic acid in ethanol
T=110°C; 2 h;
参考文献
CONSTELLATION PHARMACEUTICALS; ALBRECHT, Brian, K.; AUDIA, James, Edmund; COOK, Andrew; GAGNON, Alexandre; HARMANGE, Jean-christophe; NAVESCHUK, Christopher, G.
Patent: WO2013/75083 A1, 2013 ;
Location in patent: Paragraph 00467; 00470 ;
