2-[(2-甲氧基苯氧基)甲基]-噻唑烷合成路线 （共 7 条）
反应条件
hydrogenchloride in water; isopropyl alcohol T=79 - 80°C; 8 h; Product distribution / selectivity;
参考文献
EP2070915 A1, ;
Page/Page column 12; 13; 20 ;
反应条件
hydrogenchloride in ethanol; water 4 h; Heating;
参考文献
Journal of Medicinal Chemistry, , vol. 38, # 3 p. 508 - 525
反应条件
potassium hydrogencarbonate in water 4 h; Ambient temperature;
参考文献
Journal of Medicinal Chemistry, , vol. 38, # 3 p. 508 - 525
反应条件
1: With hydrogenchloride; benzotriazol-1-ol in acetone T=0 - 20°C; 1 h; 2: With dicyclohexyl-carbodiimide in acetone T=0 - 20°C; 5 h; Product distribution / selectivity;
参考文献
A.M.S.A. ANONIMA MATERIE SINTETICHE E AFFINI S.p.A.
Patent: EP2070915 A1, 2009 ;
Location in patent: Page/Page column 14-15; 20 ;
反应条件
potassium hydrogencarbonate in water; ethyl acetate T=0°C; 1.5 h;
参考文献
Gandolfi, Carmelo A.; Domenico, Roberto Di; Spinelli, Silvano; Gallico, Licia; Fiocchi, Luigi; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 3 p. 508 - 525
反应条件
dicyclohexyl-carbodiimide in ethyl acetate T=0°C; 6 h; Product distribution / selectivity;
参考文献
A.M.S.A. ANONIMA MATERIE SINTETICHE E AFFINI S.p.A.
Patent: EP2070915 A1, 2009 ;
Location in patent: Page/Page column 4; 13-14; 18 ;
反应条件
potassium hydrogencarbonate in ethyl acetate T=0°C; 1.5 h;
参考文献
Gandolfi, Carmelo A.; Domenico, Roberto Di; Spinelli, Silvano; Gallico, Licia; Fiocchi, Luigi; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 3 p. 508 - 525
