4-(4-二甲胺基-1-对氟苯基-1-羟基丁基)-3-(羟甲基)苯腈合成路线 （共 18 条）
反应条件
sodium carbonate in water; ethyl acetate T=25 - 35°C; 0.333333 h;
参考文献
US2010/249438 A1, ;
Page/Page column 4 ;
反应条件
1: 1-bromo-4-fluorobenzene With iodine; magnesium in tetrahydrofuran 2: 5-cyano-isobenzofuran-1-one in tetrahydrofuran; dichloromethane T=-4 - -2°C; 3: 3-(N,N-dimethylamino)-propylmagnesium chloride With ammonium chloride more than 3 stages;
参考文献
WO2006/106531 A1, ;
Page/Page column 11 ;
反应条件
sodium hydroxide in di-isopropyl ether; water pH=> 9;
参考文献
EP1700851 A1, ;
Page/Page column 9 ;
反应条件
in tetrahydrofuran; 1,1-dibromo ethane; dichloromethane; toluene T=-5 - 5°C; 3 - 4 h;
参考文献
WO2005/77927 A1, ;
Page/Page column 10-11 ;
反应条件
1: 5-cyano-isobenzofuran-1-one; (4-fluoro-phenyl)-magnesium bromide With diethylene glycol dimethyl ether; tetrabutyl-ammonium chloride in tetrahydrofuran T=0 - 20°C; Inert atmosphere; 2: 3-(N,N-dimethylamino)-propylmagnesium chloride in tetrahydrofuran T=0 - 20°C; Inert atmosphere;
参考文献
Zong, Hua; Huang, Huayin; Liu, Junfeng; Bian, Guangling; Song, Ling
Journal of Organic Chemistry, 2012 , vol. 77, # 10 p. 4645 - 4652
反应条件
1.1: iodine; magnesium / tetrahydrofuran / 5 h / 80 - 85 °C / Reflux 2.1: tetrahydrofuran / 0.25 h / -5 °C 2.2: 0.5 h / -5 - 20 °C 2.3: pH 2 View Scheme
反应条件
1.1: potassium hydroxide / water / 0 - 5 °C 1.2: 4 h / 100 - 110 °C / Reflux 2.1: tetrahydrofuran / 0.25 h / -5 °C 2.2: 0.5 h / -5 - 20 °C 2.3: pH 2 View Scheme
反应条件
1: With D-di-4-methylbenzoyl tartaric acid in isopropyl alcohol T=20°C; 12 h; Resolution of racemate; 2: With sodium hydroxide in water; toluene
参考文献
Hangzhou Minsheng Pharm. Co., Ltd.
Patent: EP1700851 A1, 2006 ;
Location in patent: Page/Page column 9 ;
反应条件
lipoprotein lipase pseudomonas sp. in 1,4-dioxane T=50°C; 504 h;
参考文献
H. LUNDBECK A/S
Patent: WO2005/77891 A1, 2005 ;
Location in patent: Page/Page column 27-28 ;
反应条件
enzyme Lipozyme TL IM; vinyl butanoate in toluene T=40°C; 16 h; Product distribution / selectivity;
参考文献
H. LUNDBECK A/S
Patent: WO2004/14821 A1, 2004 ;
Location in patent: Page 55 ;
