反应条件
1: 65 percent / 1-hydroxybenzotriazole hydrate, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / acetonitrile / 72 h / Ambient temperature
2: LiBH4, TMS-Cl / tetrahydrofuran / 20 h / Ambient temperature
View Scheme
参考文献
Smith, Paul W.; Sollis, Steven L.; Howes, Peter D.; Cherry, Peter C.; Starkey, Lan D.; Cobley, Kevin N.; Weston, Helen; Scicinski, Jan; Merritt, Andrew; Whittington, Andrew; Wyatt, Paul; Taylor, Neil; Green, Darren; Bethell, Richard; Madar, Safia; Fenton, Robert J.; Morley, Peter J.; Pateman, Tony; Beresford, Alan
Journal of Medicinal Chemistry, 1998 , vol. 41, # 6 p. 787 - 797