2-溴-2’,4’-二氟苯乙酮合成路线 （共 8 条）
反应条件
bromine; acetic acid T=10 - 30°C; 6.25 h;
参考文献
BAYER AKTIENGESELLSCHAFT
Patent: WO2003/76405 A1, 2003 ;
Location in patent: Page/Page column 71-72 ;
反应条件
aluminium trichloride
参考文献
Bartroli; Turmo; Belloc; Forn
Journal of Organic Chemistry, 1995 , vol. 60, # 10 p. 3000 - 3012
反应条件
triethylamine in acetone T=20°C; 0.5 h;
参考文献
Journal of Organometallic Chemistry, , vol. 691, # 12 p. 2686 - 2690
反应条件
in ethanol; water T=5°C; 1 h;
参考文献
BAYER AKTIENGESELLSCHAFT
Patent: WO2003/76405 A1, 2003 ;
Location in patent: Page/Page column 72 ;
反应条件
tetrabutylammomium bromide in water; toluene T=20°C; chemoselective reaction;
参考文献
Patil, Shivaraj P.; Kanawade, Shrikant B.; Shinde, Madhukar P.; Toche, Raghunath B.
Indian Journal of Heterocyclic Chemistry, 2011 , vol. 21, # 1 p. 33 - 36
反应条件
in N,N-dimethyl-formamide T=20°C;
参考文献
Acetti, Daniela; Brenna, Elisabetta; Fuganti, Claudio; Gatti, Francesco G.; Serra, Stefano
Tetrahedron Asymmetry, 2009 , vol. 20, # 20 p. 2413 - 2420
反应条件
in ethanol
T=80°C; 3 h;
参考文献
Kono, Mitsunori; Matsumoto, Takahiro; Kawamura, Toru; Nishimura, Atsushi; Kiyota, Yoshihiro; Oki, Hideyuki; Miyazaki, Junichi; Igaki, Shigeru; Behnke, Craig A.; Shimojo, Masato; Kori, Masakuni
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 1 p. 28 - 41
反应条件
1: ethanol / 3 h / 80 °C
2: hydrogen bromide / acetic acid / 3 h / 130 °C
View Scheme
参考文献
Kono, Mitsunori; Matsumoto, Takahiro; Kawamura, Toru; Nishimura, Atsushi; Kiyota, Yoshihiro; Oki, Hideyuki; Miyazaki, Junichi; Igaki, Shigeru; Behnke, Craig A.; Shimojo, Masato; Kori, Masakuni
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 1 p. 28 - 41
