4-甲氧基-2-苯基苯乙酮合成路线 （共 128 条）
反应条件
1: H2 / Pd/charcoal 2: NaOH / tetrahydrofuran; H2O 3: S2O8(2-), HClO4 / Cu(ClO4)2 / acetonitrile; H2O / 0.42 h / 83 °C / other reaction conditions, other substrate 4: pyridine-chlorochromate View Scheme
参考文献
Journal of Organic Chemistry, , vol. 49, # 9 p. 1607 - 1613
反应条件
1: S2O8(2-), HClO4 / Cu(ClO4)2 / acetonitrile; H2O / 0.42 h / 83 °C / other reaction conditions, other substrate 2: pyridine-chlorochromate View Scheme
参考文献
Journal of Organic Chemistry, , vol. 49, # 9 p. 1607 - 1613
反应条件
PPA T=60 - 80°C; Acylation; Friedel-Crafts acylation; 2 h;
参考文献
Renault, Olivier; Dallemagne, Patrick; Rault, Sylvain
Organic Preparations and Procedures International, 1999 , vol. 31, # 3 p. 324 - 328
反应条件
ethylenediamine in tetrahydrofuran 4 h; Heating;
参考文献
Mathew, Paulson; Mathew, Daliya; Asokan
Synthetic Communications, 2007 , vol. 37, # 5 p. 661 - 665
反应条件
aluminium trichloride in 1,2-dichloro-ethane T=0 - 20°C; Friedel-Crafts acylation; 2 h;
参考文献
Journal of Medicinal Chemistry, , vol. 50, # 7 p. 1475 - 1484
反应条件
potassium cyanide in N,N-dimethyl-formamide 2 h; Heating;
参考文献
Suzuki, Yumiko; Takemura, Yuki; Iwamoto, Ken-Ichi; Higashino, Takeo; Miyashita, Akira
Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 2 p. 199 - 206
反应条件
1: 4-methoxy-benzaldehyde With trimethylsilyl cyanide; zinc(II) iodide in dichloromethane T=0°C; 4 h; 2: With lithium diisopropyl amide in tetrahydrofuran; n-heptane; ethylbenzene T=-78 - -60°C; 1 h; 3: benzyl bromide With hydrogenchloride; trifluoroacetic acid more than 3 stages;
参考文献
G.D. Searle and Co.
Patent: EP1223167 A2, 2002 ;
Location in patent: Page 58 ;
反应条件
1: With 3,3-dimethyl-butan-2-one T=20°C; Oppenauer Oxidation; 3 h; Cooling with ice; 2: With trifluoroacetic acid T=20°C; 48 h;
参考文献
Fu, Ying; Yang, Yanshou; Huegel, Helmut M.; Du, Zhengyin; Wang, Kehu; Huang, Danfeng; Hu, Yulai
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 27 p. 4429 - 4432
反应条件
hydrogenchloride; tin; copper(II) sulfate
参考文献
Journal of the American Chemical Society, , vol. 53, p. 1536,1541
Journal of the American Chemical Society, , vol. 67, p. 1606
Journal of the American Chemical Society, , vol. 54, p. 1155,1161
Journal of the American Chemical Society, , vol. 54, p. 3012
反应条件
sodium hydride in tetrahydrofuran 47 h; Heating;
参考文献
Ishikawa, Yoshiharu; Kurebayashi, Yasuo; Suzuki, Kunio; Terao, Yoshiyasu; Sekiya, Minoru
Chemical and Pharmaceutical Bulletin, 1981 , vol. 29, # 9 p. 2496 - 2502
