1-苯基-1,3,8-三唑螺环(4,5)十烷-4-酮合成路线 （共 12 条）
反应条件
N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide in acetonitrile T=60°C; 12 h;
参考文献
EURO-CELTIQUE, S.A
Patent: WO2003/101953 A2, 2003 ;
Location in patent: Page 44-45 ;
WO 03/101953 A2
反应条件
potassium carbonate in various solvent(s) 24 h; Heating;
参考文献
Khorana, Nantaka; Bondarev, Mikhail; Dukat, Malgorzata; Herrick-Davis, Katharine; Egan, Christina; DuPre, Ann; Smith, Carol; Teitler, Milt; Glennon, Richard A.
Medicinal Chemistry Research, 1999 , vol. 9, # 9 p. 657 - 667
反应条件
1: With titanium(IV) isopropylate T=105°C; 2: With sodium tetrahydroborate in ethanol T=20°C;
参考文献
Pinard, Emmanuel; Ceccarelli, Simona M.; Stalder, Henri; Alberati, Daniela
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 2 p. 349 - 353
反应条件
diisopropylamine in N,N-dimethyl-formamide T=80°C; 17 h; Inert atmosphere;
参考文献
Zigelboim, Isaac; Weissberg, Avi; Cohen, Yoram
Journal of Organic Chemistry, 2013 , vol. 78, # 14 p. 7001 - 7012
反应条件
acetic acid T=20°C; Strecker reaction;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 16 p. 4321 - 4325
反应条件
sodium carbonate; potassium iodide in toluene 66 h; Heating;
参考文献
Botteghi, Carlo; Marchetti, Mauro; Paganelli, Stefano; Persi-Paoli, Francesco
Tetrahedron, 2001 , vol. 57, # 8 p. 1631 - 1637
反应条件
potassium carbonate in acetone
15 h; Heating;
参考文献
Sindelar; Metys; Protiva
Collection of Czechoslovak Chemical Communications, 1985 , vol. 50, # 5 p. 1089 - 1096
反应条件
potassium carbonate in acetone
14 h; Heating;
参考文献
Sindelar; Metys; Protiva
Collection of Czechoslovak Chemical Communications, 1985 , vol. 50, # 5 p. 1089 - 1096
反应条件
4-methyl-morpholine; triethylamine in tetrahydrofuran; chloroform
参考文献
E. R. Squibb and Sons, Inc.
Patent: US4051248 A1, 1977 ;
反应条件
diisopropylamine in N,N-dimethyl-formamide
T=80°C; 17 h; Inert atmosphere;
参考文献
Zigelboim, Isaac; Weissberg, Avi; Cohen, Yoram
Journal of Organic Chemistry, 2013 , vol. 78, # 14 p. 7001 - 7012
