1-乙酰基-1,2-二氢喹啉合成路线 （共 16 条）
反应条件
1: quinoline With diisobutylaluminium hydride in diethyl ether; toluene T=0°C; 2.5 h; 2: acetic anhydride in diethyl ether; toluene T=0°C; 1 h;
参考文献
MEDIVIR AB
Patent: WO2005/66131 A1, 2005 ;
Location in patent: Page/Page column 61 ;
反应条件
Grubb's 2nd generation catalyst in benzene T=20°C; 20 h;
参考文献
Rosillo, Marta; Dominguez, Gema; Casarrubios, Luis; Amador, Ulises; Perez-Castells, Javier
Journal of Organic Chemistry, 2004 , vol. 69, # 6 p. 2084 - 2093
反应条件
1: With sodium tetrahydroborate T=0 - 60°C; 2 h; 2: With sodium hydroxide in water pH=10;
参考文献
Peglion, Jean-Louis; Dessinges, Aimee; Goument, Bertrand; Millan, Mark; La Cour, Clotilde Mannoury
Patent: US2006/229318 A1, 2006 ;
Location in patent: Page/Page column 19 ;
US 20060229318 A1
反应条件
sodium tetrahydroborate in acetic acid T=0 - 50°C; 2 h; Inert atmosphere;
参考文献
Tiwari, Virendra Kumar; Pawar, Govind Goroba; Das, Riki; Adhikary, Amit; Kapur, Manmohan
Organic Letters, 2013 , vol. 15, # 13 p. 3310 - 3313
反应条件
1: 98 percent / Bu4NI; KOH / tetrahydrofuran 2: 100 percent / H2 / Lindlar catalyst / ethyl acetate / 20 h / 760 Torr 3: 96 percent / [1,3-dimesitylimidazolidin-2-yl]Cl2(PCy3)Ru=CHPh / benzene / 20 h / 20 °C View Scheme
参考文献
Rosillo, Marta; Dominguez, Gema; Casarrubios, Luis; Amador, Ulises; Perez-Castells, Javier
Journal of Organic Chemistry, 2004 , vol. 69, # 6 p. 2084 - 2093
反应条件
1: 100 percent / H2 / Lindlar catalyst / ethyl acetate / 20 h / 760 Torr 2: 96 percent / [1,3-dimesitylimidazolidin-2-yl]Cl2(PCy3)Ru=CHPh / benzene / 20 h / 20 °C View Scheme
参考文献
Rosillo, Marta; Dominguez, Gema; Casarrubios, Luis; Amador, Ulises; Perez-Castells, Javier
Journal of Organic Chemistry, 2004 , vol. 69, # 6 p. 2084 - 2093
反应条件
toluene-4-sulfonic acid in toluene 0.5 h; Heating;
参考文献
Toekes, Adrienne L.; Antus, Sandor
Liebigs Annalen der Chemie, 1994 , # 9 p. 911 - 916
反应条件
sodium tetrahydroborate in acetic acid T=60°C; 2 h; var. anhydride; Product distribution;
参考文献
Katayama, Hajime; Ohkoshi, Mitsuko; Yasue, Masaiti
Chemical & Pharmaceutical Bulletin, 1980 , vol. 28, # 7 p. 2226 - 2228
反应条件
pyridine 1 h; Ambient temperature;
参考文献
Toekes, Adrienne L.; Antus, Sandor
Liebigs Annalen der Chemie, 1994 , # 9 p. 911 - 916
反应条件
1: 30 percent / pyridine / 2 h / Heating 2: 89 percent / NaBH4 / methanol / 0.17 h 3: 56 percent / p-TsOH / toluene / 0.5 h / Heating View Scheme
参考文献
Toekes, Adrienne L.; Antus, Sandor
Liebigs Annalen der Chemie, 1994 , # 9 p. 911 - 916
