2-苯基-1-吡啶-4-乙酮合成路线 （共 16 条）
反应条件
lithium bromide in diethyl ether
T=-5 - 0°C; protected from light;
参考文献
Loeschorn, Carol A.; Nakajima, Masayuki; McCloskey, Patrick J.; Anselme, Jean-Pierre
Journal of Organic Chemistry, 1983 , vol. 48, # 23 p. 4407 - 4410
反应条件
in tetrahydrofuran
T=-78°C; 2 h;
参考文献
N30 PHARMACEUTICALS, LLC; SUN, Xicheng; QIU, Jian
Patent: WO2011/38204 A1, 2011 ;
Location in patent: Page/Page column 146-147 ;
WO 2011/038204 A1
反应条件
hydrogenchloride; magnesium in water
参考文献
Hoechst Aktiengesellschaft
Patent: US4547508 A1, 1985 ;
反应条件
1: sodium ethoxide / ethanol / 2 h / Heating
2: hydrobromic acid / propan-2-ol; diethyl ether / 12 h / Heating
3: aqueous sodium bicarbonate
View Scheme
参考文献
Bunting, John W.; Stefanides, Dimitrios
Journal of the American Chemical Society, 1988 , vol. 110, # 12 p. 4008 - 4017
反应条件
1: ethanol; diethyl ether
2: 50 percent / 10percent methanolic potassium hydroxide / tetrahydrofuran; diethyl ether; acetone / -40 °C
3: conc. hydrochloric acid / ethanol
4: aqueous sodium bicaebonate
View Scheme
参考文献
Bunting, John W.; Stefanides, Dimitrios
Journal of the American Chemical Society, 1988 , vol. 110, # 12 p. 4008 - 4017
反应条件
1: sodium ethoxide / ethanol / 2 h / Heating
2: hydrobromic acid / propan-2-ol; diethyl ether / 12 h / Heating
3: aqueous sodium bicarbonate
View Scheme
参考文献
Bunting, John W.; Stefanides, Dimitrios
Journal of the American Chemical Society, 1988 , vol. 110, # 12 p. 4008 - 4017
反应条件
sodium hydrogencarbonate
参考文献
Bunting, John W.; Stefanides, Dimitrios
Journal of the American Chemical Society, 1988 , vol. 110, # 12 p. 4008 - 4017
反应条件
sodium hydrogencarbonate
参考文献
Bunting, John W.; Stefanides, Dimitrios
Journal of the American Chemical Society, 1988 , vol. 110, # 12 p. 4008 - 4017
反应条件
water in diethyl ether
参考文献
Richter, Isabella; Minari, Jusaku; Axe, Philip; Lowe, John P.; James, Tony D.; Sakurai, Kazuo; Bull, Steven D.; Fossey, John S.
Chemical Communications, 2008 , # 9 p. 1082 - 1084
反应条件
1: 83 percent / propan-2-ol; various solvent(s) / 4 h / Ambient temperature
2: anh. Cs2CO3 / tetrahydrofuran; propan-2-ol / 16 h / Ambient temperature
3: 3N HCl / H2O; tetrahydrofuran; propan-2-ol / 2 h / Ambient temperature
View Scheme
参考文献
Journet, Michel; Cai, Dongwei; Larsen, Robert D.; Reider, Paul J.
Tetrahedron Letters, 1998 , vol. 39, # 13 p. 1717 - 1720
