(2-氯吡啶-3-基)乙腈合成路线 （共 19 条）
反应条件
trichlorophosphate T=80°C; 4.5 h; Heating / reflux;
参考文献
Aventis Pharmaceuticals Inc.
Patent: US2005/54631 A1, 2005 ;
Location in patent: Page/Page column 23-24 ;
反应条件
in dimethyl sulfoxide T=50°C; 4 h;
参考文献
Takeda Pharmaceutical Company Limited
Patent: EP2018863 A1, 2009 ;
Location in patent: Page/Page column 74 ;
反应条件
in ethanol; water 3 h; Heating / reflux;
参考文献
UCB PHARMA S.A.
Patent: WO2009/13462 A1, 2009 ;
Location in patent: Page/Page column 25-26 ;
WO 2009/013462 A1
反应条件
in ethanol; water 3 h; RefluxInert atmosphere;
参考文献
UCB PHARMA S.A.
Patent: WO2009/93008 A1, 2009 ;
Location in patent: Page/Page column 25 ;
反应条件
in ethanol; water 3 h; Inert atmosphereReflux;
参考文献
UCB PHARMA S.A.
Patent: WO2009/153554 A1, 2009 ;
Location in patent: Page/Page column 35-36 ;
WO 2009/153554 A1
反应条件
in ethanol; water T=25°C; 12 h; Reflux;
参考文献
Yu, Gang; Praveen Rao; Chowdhury, Morshed A.; Abdellatif, Khaled R.A.; Dong, Ying; Das, Dipankar; Velazquez, Carlos A.; Suresh, Mavanur R.; Knaus, Edward E.
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 7 p. 2168 - 2173
反应条件
1: CH3CO3H / Heating 2: POCl3 / 80 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 33, # 10 p. 2697 - 2706
反应条件
1: aqueous ethanol 2: H2O2; aqueous acetic acid 3: POCl3 View Scheme
参考文献
Journal of the American Chemical Society, , vol. 81, p. 740,742
反应条件
trichlorophosphate T=80°C;
参考文献
Journal of Medicinal Chemistry, , vol. 33, # 10 p. 2697 - 2706
反应条件
trichlorophosphate 3 h; Heating;
参考文献
Synthesis, , # 6 p. 528 - 530
