4'-氯-4-氨基二苯醚合成路线 （共 21 条）
反应条件
hydrogenchloride; tin in ethanol; water 1 h; Reflux;
参考文献
Journal of Medicinal Chemistry, , vol. 56, # 11 p. 4811 - 4815
反应条件
1: Cs2CO3; dimethylamine View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 12, # 16 p. 4477 - 4492
反应条件
1: Cs2CO3; dimethylamine View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 12, # 16 p. 4477 - 4492
反应条件
1: 1) KOH, 2) Cu-catalyst / 1) 130-140 deg C, 2) 150-160 deg C, 30 min 2: 70 percent / H2 / Ra-Ni / methanol / 6 h / 3102.9 - 3878.6 Torr / Ambient temperature; different reagent View Scheme
参考文献
Pharmazie, , vol. 35, # 2 p. 78 - 80
反应条件
1: CuCl2, pyridine 2: H2 / Pd-C View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 34, # 2 p. 701 - 712
反应条件
1: caesium carbonate / N,N-dimethyl-formamide; acetonitrile / 20 °C 2: iron; acetic acid / water; ethanol / 0.5 h / 80 °C View Scheme
反应条件
copper(I) oxide; ammonia; water T=170°C;
反应条件
1: glacial acetic acid; chlorine 2: tin (II)-chloride; etheric hydrochloric acid View Scheme
参考文献
Journal of the Chemical Society, , p. 2367
反应条件
sulfuric acid in ethanol T=20°C; MechanismRate constant;
参考文献
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), , p. 1377 - 1382
反应条件
in dichloromethane T=0 - 20°C; 1.5 h;
参考文献
JANSSEN PHARMACEUTICA, N.V.
Patent: WO2005/44810 A1, 2005 ;
Location in patent: Page/Page column 51-52 ;
WO 2005/044810 A1
