2,3-二氢苯并[1,4]二恶烷-2-甲腈合成路线 (共 16 条)
反应条件
potassium carbonate in acetone 18 h; Heating;
参考文献
Davrinche; Nguyen-Tri-Xuong; Reynaud; Arnould-Guerin; Tran; Rinjard; Pieri
European Journal of Medicinal Chemistry, 1990 , vol. 25, # 5 p. 397 - 401
反应条件
potassium carbonate in acetone 12 h; Heating;
参考文献
Tomiyama; Wakabayashi; Yokota
Journal of Medicinal Chemistry, 1989 , vol. 32, # 8 p. 1988 - 1996
反应条件
1: 98 percent / HOAc, conc. H2SO4 / H2O / 15 h / 110 °C 2: 97 percent / conc. H2SO4 / 1 h / Heating View Scheme
参考文献
Tomiyama; Wakabayashi; Yokota
Journal of Medicinal Chemistry, 1989 , vol. 32, # 8 p. 1988 - 1996
反应条件
hydrogenchloride; hydrogen; platinum(IV) oxide in methanol T=20°C; Catalytic hydrogenation; P=760 Torr; 36 h;
参考文献
Sanchez, Isabel; Dolors Pujol, Maria; Guillaumet, Gerald; Massingham, Roy; Monteil, Andre; Dureng, Georges; Winslow, Eileen
European Journal of Medicinal Chemistry, 2000 , vol. 35, # 7-8 p. 663 - 676
反应条件
sulfuric acid; acetic acid in water T=110°C; 15 h;
参考文献
Tomiyama; Wakabayashi; Yokota
Journal of Medicinal Chemistry, 1989 , vol. 32, # 8 p. 1988 - 1996
反应条件
sulfuric acid; acetic acid in water T=110°C; 15 h;
参考文献
Journal of Medicinal Chemistry, , vol. 32, # 8 p. 1988 - 1996
反应条件
1: 83 percent / HCl / diethyl ether / 24 h / 0 - 10 °C 2: ethanol / 24 h / 0 - 10 °C View Scheme
参考文献
Chapleo; Myers; Butler; Doxey; Roach; Smith
Journal of Medicinal Chemistry, 1983 , vol. 26, # 6 p. 823 - 831
反应条件
1: 2,3-Dihydro-1,4-benzodioxin-2-carbonitrile With hydrogenchloride; sodium methylate in methanol T=20°C; 4 h; 2: ethylenediamine With hydrogenchloride in methanol T=0 - 10°C; 20 h;
参考文献
Bougaret, Joel; Avan, Jean-Louis; Segonds, Roland
Patent: US2005/90537 A1, 2005 ;
Location in patent: Page/Page column 8; 9 ;
反应条件
1: HCl / diethyl ether 2: 2.) HCl View Scheme
参考文献
Chapleo, Christopher B.; Myers, Peter L.
Tetrahedron Letters, 1981 , vol. 22, # 48 p. 4839 - 4842
反应条件
sulfuric acid; acetic acid in water T=110°C; 15 h;
参考文献
Tomiyama; Wakabayashi; Yokota
Journal of Medicinal Chemistry, 1989 , vol. 32, # 8 p. 1988 - 1996