反应条件
1: methanol; sodium tetrahydroborate / 0.5 h / 0 - 10 °C 2: thionyl chloride / dichloromethane / 2 h / 20 °C 3: potassium hydroxide; N-benzyl-N,N,N-triethylammonium chloride / toluene / 20 °C / |Inert atmosphere 4: anhydrous xylene / 48 h / 150 °C / |Inert atmosphere 5: water; barium hydroxide / 120 °C View Scheme
参考文献
GENENTECH, INC.; FORMA TM, LLC; BAIR, Kenneth, W.; BAUMEISTER, Timm, R.; GOSSELIN, Francis; ZAK, Mark; ZHENG, Xiaozhang
Patent: WO2013/130935 A1, 2013 ;