3-溴-4-氟苯甲酸合成路线

Rheault, Tara R.; Stellwagen, John C.; Adjabeng, George M.; Hornberger, Keith R.; Petrov, Kimberly G.; Waterson, Alex G.; Dickerson, Scott H.; Mook, Robert A.; Laquerre, Sylvie G.; King, Alastair J.; Rossanese, Olivia W.; Arnone, Marc R.; Smitheman, Kimberly N.; Kane-Carson, Laurie S.; Han, Chao; Moorthy, Ganesh S.; Moss, Katherine G.; Uehling, David E.
ACS Medicinal Chemistry Letters, 2013 , vol. 4, # 3 p. 358 - 362

64-17-5乙醇+

1007-16-53-溴-4-氟苯甲酸

23233-33-23-溴-4-氟苯甲酸乙酯

参考文献

Ebisawa, Masaru; Ueno, Masahiro; Oshima, Yoshiteru; Kondo, Yoshinori
Tetrahedron Letters, 2007 , vol. 48, # 50 p. 8918 - 8921

67-56-1甲醇+

1007-16-53-溴-4-氟苯甲酸

82702-31-63-溴-4-氟苯甲酸甲酯

参考文献

Scribner, Andrew; Dennis, Richard; Hong, Jean; Lee, Shuliang; McIntyre, Donald; Perrey, David; Feng, Dennis; Fisher, Michael; Wyvratt, Matthew; Leavitt, Penny; Liberator, Paul; Gurnett, Anne; Brown, Chris; Mathew, John; Thompson, Donald; Schmatz, Dennis; Biftu, Tesfaye
European Journal of Medicinal Chemistry, 2007 , vol. 42, # 11-12 p. 1334 - 1357

1007-16-53-溴-4-氟苯甲酸+

18107-18-1三甲基硅烷化重氮甲烷

82702-31-63-溴-4-氟苯甲酸甲酯

参考文献

VERTEX PHARMACEUTICALS INCORPORATED
Patent: WO2004/78733 A1, 2004 ;
Location in patent: Page 436 ;
WO 2004/078733 A1

1007-16-53-溴-4-氟苯甲酸

82702-31-63-溴-4-氟苯甲酸甲酯

参考文献

Millennium Pharmaceuticals, Inc.
Patent: US2005/256158 A1, 2005 ;
US 20050256158 A1