(2-甲基烯丙氧基)-乙酸合成路线 （共 7 条）
反应条件
sodium hydride in tetrahydrofuran Heating;
参考文献
Li, Wenke; Wayne, Gregory S.; Lallaman, John E.; Chang, Sou-Jen; Wittenberger, Steven J.
Journal of Organic Chemistry, 2006 , vol. 71, # 4 p. 1725 - 1727
反应条件
1: 2-methyl-prop-2-en-1-ol With sodium hydride in tetrahydrofuran T=20°C; Metallation; 2: monobromoacetic acid in tetrahydrofuran T=20°C; Etherification;
参考文献
Sato, Yoshinori; Fujisawa, Hidehiko; Mukaiyama, Teruaki
Bulletin of the Chemical Society of Japan, 2006 , vol. 79, # 8 p. 1275 - 1287
反应条件
in tetrahydrofuran T=60°C; 16 h;
参考文献
MERCK PATENT GMBH
Patent: WO2006/125529 A1, 2006 ;
Location in patent: Page/Page column 44-45 ;
反应条件
1: 79 percent Chromat. / Amberlyst-15 ion-exchange resin / 8 h / 60 °C 2: 89 percent Chromat. / potassium osmate dihydrate; sodium periodate / H2O; tetrahydrofuran / 11 h / 20 °C 3: 78 percent / sodium tert-butoxide / tetrahydrofuran / 1.08 h / 65 °C View Scheme
参考文献
Li, Wenke; Wayne, Gregory S.; Lallaman, John E.; Chang, Sou-Jen; Wittenberger, Steven J.
Journal of Organic Chemistry, 2006 , vol. 71, # 4 p. 1725 - 1727
反应条件
potassium carbonate in N,N-dimethyl-formamide T=20°C;
参考文献
Oh, Taeboem; Wrobel, Zbigniew; Rubenstein, Steven M.
Tetrahedron Letters, 1991 , vol. 32, # 36 p. 4647 - 4650
反应条件
Amberlyst-15 ion-exchange resin T=60°C; 8 h;
参考文献
Li, Wenke; Wayne, Gregory S.; Lallaman, John E.; Chang, Sou-Jen; Wittenberger, Steven J.
Journal of Organic Chemistry, 2006 , vol. 71, # 4 p. 1725 - 1727
反应条件
1: 79 percent Chromat. / Amberlyst-15 ion-exchange resin / 8 h / 60 °C
2: 89 percent Chromat. / potassium osmate dihydrate; sodium periodate / H2O; tetrahydrofuran / 11 h / 20 °C
View Scheme
参考文献
Li, Wenke; Wayne, Gregory S.; Lallaman, John E.; Chang, Sou-Jen; Wittenberger, Steven J.
Journal of Organic Chemistry, 2006 , vol. 71, # 4 p. 1725 - 1727
