1: With 4 A molecular sieve; triphenyl-phosphine oxide; (R)-BINOLAM; dimethylaluminum chloride in hexane; toluene T=-20°C; 24 h; 2: With hydrogenchloride in water; ethyl acetate; toluene 1 h; Title compound not separated from byproducts;
参考文献
Casas, Jesus; Najera, Carmen; Sansano, Jose M.; Saa, Jose M.
Tetrahedron, 2004 , vol. 60, # 46 SPEC. ISS. p. 10487 - 10496
(3S,6S)-3-benzyl-6-(4-imidazolylmethyl)piperazine-2,5-dione in toluene T=-5°C; 14 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;