(R)-(+)-4-甲基苯乙醇腈合成路线 （共 14 条）
反应条件
1: trimethylsilyl cyanide With methanol; C60H48LiN2O4P2Ru(1+)*Cl(1-) Inert atmosphereCooling; 2: 4-methyl-benzaldehyde in tert-butyl methyl ether T=-70°C; 24 h; Inert atmosphere; optical yield given as percent eeenantioselective reaction;
参考文献
Kurono, Nobuhito; Yoshikawa, Tatsuya; Yamasaki, Mikio; Ohkuma, Takeshi
Organic Letters, 2011 , vol. 13, # 5 p. 1254 - 1257
反应条件
in ethyl acetate 48 h; Ambient temperature(E.C. 4.1.2.10), 1000 U/ml, sodium acetate buffer pH 5.4;
参考文献
Ziegler, Thomas; Hoersch, Brigitte; Effenberger, Franz
Synthesis, 1990 , # 7 p. 575 - 578
反应条件
1: 4-methyl-benzaldehyde With (1R,2R)-cyclohexane-1,2-diylbis(2-azaethenyl-3-tert-butyl-2-hydroxybenzo-5-sulfonic acid) disodium salt; Manganese (II) acetate in methanol T=20°C; 0.5 h; 2: sodium cyanide in methanol T=20°C; 24 h; optical yield given as percent eeenantioselective reaction;
参考文献
Qu, Yanyang; Jing, Linhai; Wu, Zhiqing; Wu, Di; Zhou, Xiangge
Tetrahedron Asymmetry, 2010 , vol. 21, # 2 p. 187 - 190
反应条件
chiral binaphthol lantanum alkoxide in dichloromethane T=-78°C; 10 h; other chiral binaphthol-modified lanthanum alkoxides; Product distribution;
参考文献
Hayashi, Masahiko; Miyamoto, Yasunori; Inoue, Tetsuya; Oguni, Nobuki
Journal of the Chemical Society, Chemical Communications, 1991 , # 24 p. 1752 - 1753
反应条件
in di-isopropyl ether T=5°C; 48 h; almond meal oxynitrilase, 0.1 M tartrate buffer, pH 5.4;
参考文献
Kiljunen, Eero; Kanerva, Liisa T.
Tetrahedron Asymmetry, 1996 , vol. 7, # 4 p. 1105 - 1116
反应条件
hydrogenchloride in diethyl ether
参考文献
Kurono, Nobuhito; Arai, Kenta; Uemura, Masato; Ohkuma, Takeshi
Angewandte Chemie - International Edition, 2008 , vol. 47, # 35 p. 6643 - 6646
反应条件
Prunus mume (R)-hydroxynitrile lyase; citrate buffer in di-isopropyl ether pH=4.0; 42 h;
参考文献
Nanda, Samik; Kato, Yasuo; Asano, Yasuhisa
Tetrahedron, 2005 , vol. 61, # 46 p. 10908 - 10916
反应条件
(3S,6S)-3-benzyl-6-(4-imidazolylmethyl)piperazine-2,5-dione in toluene T=-5°C; 3 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Mori, Atsunori; Ikeda, Yoshitaka; Kinoshita, Koichi; Inoue, Shohei
Chemistry Letters, 1989 , p. 2119 - 2122
反应条件
hydrogenchloride Ambient temperature; Title compound not separated from byproducts;
参考文献
Blocka, Ewelina; Bosiak, Mariusz J.; Welniak, Miroslaw; Ludwiczak, Agnieszka; Wojtczak, Andrzej
Tetrahedron Asymmetry, 2014 , vol. 25, # 6-7 p. 554 - 562
反应条件
lipase PS-30 in diethyl ether T=15°C; 23.5 h; Enzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Xu, Qing; Xie, Yongli; Geng, Xiaohong; Chen, Peiran
Tetrahedron, 2010 , vol. 66, # 3 p. 624 - 630
