3-甲基戊酸

3-甲基戊酸

DL-3-Methylvaleric acid

105-43-1

C6H12O2

116.15800

37.30000

1.50720

116.08400

n20/D 1.416(lit.)

无色液体带有一种恶臭

185 °F

196-198 °C(lit.)

-41 °C

insoluble

0.93 g/mL at 25 °C(lit.)

0.147mmHg at 25°C

Stable at room temperature in closed containers under normal storage and handling conditions.

Keep away from heat, sparks, and flame. Keep away from sources of ignition. Keep container closed when not in use. Store in a cool, dry, well-ventilated area away from incompatible substances. Corrosives area.

8

3

S26-S36/37/39-S45

II

UN 3265 8/PG 2

2915600000

C

R34

2933990090

2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

<p>1.将200g氢氧化钾溶于200ml水,搅拌加热,滴加200g仲丁基丙二酸二乙酯,皂化反应放热,反应液平稳回流2h。然后用200ml水稀释,蒸出皂化生成的乙醇。剩余的反应产物冷却后加入320g浓硫酸和450ml水,回流3h。蒸出生成的有机酸,分馏提纯,得66-69g 3-甲基戊酸,收率62%-65%。 <br>2. 烟草:OR,26,44, 49;FC,9, 18;BU,OR,18;BU,9;OR,41;FC,BU,OR,40;BU,26。 <br>3.制法: 于装有搅拌器、回流冷凝器的反应瓶中,加入水200mL,氢氧化钾200g,搅拌溶解。慢慢加入仲丁基丙二酸二乙酯<br>(2)200g(0.92mol),使反应体系回流3h。加入水200mL,蒸馏,约蒸出200mL液体,以除去反应中生成的乙醇。向反应液中慢慢加入由320g硫酸和450mL水配成的冷烯酸。加完后回流反应3h。而后进行水蒸气蒸馏直至无油状物镏出。镏出液中的水,可分次倒入反应瓶中,最后约剩水100mL。分出有机层,水层用乙醚提取两次。合并油层和乙醚层,蒸出乙醚后,再加入等体积的苯,利用苯与水可生成共沸物的特点除去其中的水,最后蒸馏,收集193～196℃的馏分,得3-甲基戊酸<br>(1)68g,收率64%。 </p>

<p>OB2760—1996规定为暂时允许使用的食品用香料。本品还可用于有机合成。</p>