bis(triphenylphosphine)palladium(II)-chloride; triethylamine in N,N-dimethyl-formamide T=75°C; 18 h;

1: AsPh3; NMP / Pd2dba3 / 40 °C 2: 91 percent / KOH / ethanol; H2O / 70 °C View Scheme

triphenyl-arsane; bis(dibenzylideneacetone)-palladium(0) in 1-methyl-pyrrolidin-2-one T=50°C; Substitution; Stille reaction; 5 h;

1: AsPh3; NMP / Pd2dba3 / 40 °C 2: 91 percent / KOH / ethanol; H2O / 70 °C View Scheme

1: AsPh3; NMP / Pd2dba3 / 40 °C 2: 91 percent / KOH / ethanol; H2O / 70 °C View Scheme

Stage #1: <a href="#" onclick="return RXDsubstances(event, this, '1905593', constants.ctx, '0')">2,6,6-trimethyl-cyclohexan-1-one</a> <b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '906717', constants.ctx, '0')">lithium diisopropyl amide</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '102391', constants.ctx, '0')">tetrahydrofuran</a> <br />T=-78&deg;C;&nbsp;3&nbsp;h;&nbsp;&nbsp;Inert atmosphere;&nbsp;<br />Stage #2: <a href="#" onclick="return RXDsubstances(event, this, '1269141', constants.ctx, '0')">N,N-bis(trifluoromethanesulfonyl)aniline</a> &nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '102391', constants.ctx, '0')">tetrahydrofuran</a> <br />T=-78 - 20&deg;C;&nbsp;<br /> <br /> &nbsp;