2-甲基-4-溴苯甲酸甲酯合成路线

参考文献

EXELIXIS, INC.
Patent: WO2009/55077 A1, 2009 ;
Location in patent: Page/Page column 430 ;

参考文献

Li, Qun; Woods, Keith W.; Zhu, Gui-Dong; Fischer, John P.; Gong, Jianchun; Li, Tongmei; Gandhi, Virajkumar; Thomas, Sheela A.; Packard, Garrick K.; Song, Xiaohong; Abrams, Jason N.; Diebold, Robert; Dinges, Jurgen; Hutchins, Charles; Stoll, Vincent S.; Rosenberg, Saul H.; Giranda, Vincent L.
Patent: US2003/187026 A1, 2003 ;
US 20030187026 A1

68837-59-24-溴-2-甲基苯甲酸+

74-88-4甲基碘

99548-55-72-甲基-4-溴苯甲酸甲酯

参考文献

CELGENE CORPORATION
Patent: WO2008/27542 A2, 2008 ;
Location in patent: Page/Page column 89-90 ;

67-56-1甲醇+

68837-59-24-溴-2-甲基苯甲酸

99548-55-72-甲基-4-溴苯甲酸甲酯

参考文献

Sun, Xicheng; Qiu, Jian; Strong, Sarah A.; Green, Louis S.; Wasley, Jan W.F.; Colagiovanni, Dorothy B.; Mutka, Sarah C.; Blonder, Joan P.; Stout, Adam M.; Richards, Jane P.; Chun, Lawrence; Rosenthal, Gary J.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 12 p. 3671 - 3675

67832-11-54-溴-2-甲基苯腈

99548-55-72-甲基-4-溴苯甲酸甲酯

参考文献

Bioorganic and Medicinal Chemistry Letters, , vol. 23, # 21 p. 5936 - 5940

67-56-1甲醇+

21900-45-84-溴-2-甲基苯甲酰氯

99548-55-72-甲基-4-溴苯甲酸甲酯

参考文献

US2006/194801 A1, ;

Page/Page column 47 ;

68837-59-24-溴-2-甲基苯甲酸+

77-78-1硫酸二甲酯

99548-55-72-甲基-4-溴苯甲酸甲酯

参考文献

Bioorganic and Medicinal Chemistry Letters, , vol. 23, # 21 p. 5936 - 5940

99548-55-72-甲基-4-溴苯甲酸甲酯

35598-05-14-甲氧基-2-甲基苯甲酸甲酯

参考文献

Yamabe, Haruko; Okuyama, Masahiro; Nakao, Akira; Ooizumi, Mitsuru; Saito, Ken-ichi
Patent: US2003/212094 A1, 2003 ;

99548-55-72-甲基-4-溴苯甲酸甲酯

1975-53-74-氰基-2-甲基苯甲酸

参考文献

Sun, Xicheng; Qiu, Jian; Strong, Sarah A.; Green, Louis S.; Wasley, Jan W.F.; Colagiovanni, Dorothy B.; Mutka, Sarah C.; Blonder, Joan P.; Stout, Adam M.; Richards, Jane P.; Chun, Lawrence; Rosenthal, Gary J.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 12 p. 3671 - 3675

99548-55-72-甲基-4-溴苯甲酸甲酯

215800-05-82-(4-溴-2-甲基苯基)乙腈

参考文献

AFRAXIS, INC.; CAMPBELL, David; DURÓN, Sergio, G.
Patent: WO2013/43232 A2, 2013 ;
WO 2013/043232 A2