2-甲基-3-溴苯甲酸甲酯合成路线

参考文献

Takeda Chemical Industries, Ltd.
Patent: US6518257 B1, 2003 ;

99548-54-62-甲基-3-溴苯甲酸甲酯+

79669-50-42-甲基-5-溴苯甲酸甲酯

79670-17-05-溴-2-溴甲苯甲酸甲酯+

337536-14-83-溴-2-溴甲基苯甲酸甲酯

参考文献

Wyeth
Patent: US2007/203116 A1, 2007 ;
Location in patent: Page/Page column 8; 10 ;
US 20070203116 A1

99548-54-62-甲基-3-溴苯甲酸甲酯

337536-15-94-溴异吲哚啉-1-酮

参考文献

Curtin, Michael L.; Frey, Robin R.; Heyman, H. Robin; Sarris, Kathy A.; Steinman, Douglas H.; Holmes, James H.; Bousquet, Peter F.; Cunha, George A.; Moskey, Maria D.; Ahmed, Asma A.; Pease, Lori J.; Glaser, Keith B.; Stewart, Kent D.; Davidsen, Steven K.; Michaelides, Michael R.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 17 p. 4505 - 4509

99548-54-62-甲基-3-溴苯甲酸甲酯+

79669-50-42-甲基-5-溴苯甲酸甲酯

79670-17-05-溴-2-溴甲苯甲酸甲酯+

337536-14-83-溴-2-溴甲基苯甲酸甲酯

参考文献

Wyeth
Patent: US2007/203116 A1, 2007 ;
Location in patent: Page/Page column 8; 10 ;
US 20070203116 A1

99548-54-62-甲基-3-溴苯甲酸甲酯+

73183-34-3联硼酸频那醇酯

955929-54-12-甲基-3-(4,4,5,5-四甲基-1,3,2-二噁硼烷-2-基)苯甲酸甲酯

参考文献

Negoro, Kenji; Ohnuki, Kei; Yonetoku, Yasuhiro; Kuramoto, Kazuyuki; Urano, Yasuharu; Watanabe, Hideyuki
Patent: US2012/35196 A1, 2012 ;
Location in patent: Page/Page column 21 ;

99548-54-62-甲基-3-溴苯甲酸甲酯

765948-78-52,3-二氢-4-(4,4,5,5-四甲基-1,3,2-二氧硼烷)-1H-异吲哚-1-酮

参考文献

Curtin, Michael L.; Frey, Robin R.; Heyman, H. Robin; Sarris, Kathy A.; Steinman, Douglas H.; Holmes, James H.; Bousquet, Peter F.; Cunha, George A.; Moskey, Maria D.; Ahmed, Asma A.; Pease, Lori J.; Glaser, Keith B.; Stewart, Kent D.; Davidsen, Steven K.; Michaelides, Michael R.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 17 p. 4505 - 4509

99548-54-62-甲基-3-溴苯甲酸甲酯

102308-43-04-溴-2-苯并呋喃-1(3H)-酮

参考文献

Xiao, Xiangshu; Antony, Smitha; Pommier, Yves; Cushman, Mark
Journal of Medicinal Chemistry, 2006 , vol. 49, # 4 p. 1408 - 1412

99548-54-62-甲基-3-溴苯甲酸甲酯

102308-43-04-溴-2-苯并呋喃-1(3H)-酮+

914220-72-73-溴-2-氯甲苯甲酸甲酯

参考文献

Zhang, Peng; Cyriac, George; Kopajtic, Theresa; Zhao, Yongfang; Javitch, Jonathan A.; Katz, Jonathan L.; Newman, Amy Hauck
Journal of Medicinal Chemistry, 2010 , vol. 53, # 16 p. 6112 - 6121

99548-54-62-甲基-3-溴苯甲酸甲酯

765948-62-74-(4-氨基苯基)-2,3-二氢-1H-异吲哚-1-酮

参考文献

Curtin, Michael L.; Frey, Robin R.; Heyman, H. Robin; Sarris, Kathy A.; Steinman, Douglas H.; Holmes, James H.; Bousquet, Peter F.; Cunha, George A.; Moskey, Maria D.; Ahmed, Asma A.; Pease, Lori J.; Glaser, Keith B.; Stewart, Kent D.; Davidsen, Steven K.; Michaelides, Michael R.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 17 p. 4505 - 4509

99548-54-62-甲基-3-溴苯甲酸甲酯

83647-43-23-溴-2-甲基苯甲醇

参考文献

TAKEDA PHARMACEUTICAL COMPANY LIMITED; NEGORO, Nobuyuki; TERAO, Yoshito; MIKAMI, Satoshi; YUKAWA, Tomoya
Patent: WO2010/143733 A1, 2010 ;
Location in patent: Page/Page column 347-348 ;
WO 2010/143733 A1