2-(2-碘-5-甲氧基苯基)-N,N-二甲基乙酰胺合成路线 （共 7 条）
反应条件
N-iodo-succinimide in acetonitrile 12 h; Heating;
参考文献
Kenny, Jane R.; Maggs, James L.; Meng, Xiaoli; Sinnott, Deborah; Clarke, Stephen E.; Park, B. Kevin; Stachulski, Andrew V.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 11 p. 2816 - 2825
反应条件
in dichloromethane; N,N-dimethyl-formamide; toluene
反应条件
in N,N-dimethyl-formamide 3 h; Ambient temperature;
参考文献
Carson; Almond; Brannan; Carmosin; Flaim; Gill; Gleason; Keely; Ludovici; Pitis; Rebarchak; Villani
Journal of Medicinal Chemistry, 1988 , vol. 31, # 3 p. 630 - 636
反应条件
1: oxalyl chloride / dimethylformamide / 16 h / Ambient temperature 2: 80 percent / dimethylformamide / 3 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 31, # 3 p. 630 - 636
反应条件
1: 91 percent / K2CO3; CuI; Cu / toluene / 24 h / Heating 2: 90 percent / BBr3 / CH2Cl2; 1,2-dichloro-ethane / 20 °C 3: 80 percent / aq. NaOH / ethanol / 36 h / 80 °C View Scheme
参考文献
Kenny, Jane R.; Maggs, James L.; Meng, Xiaoli; Sinnott, Deborah; Clarke, Stephen E.; Park, B. Kevin; Stachulski, Andrew V.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 11 p. 2816 - 2825
反应条件
copper(l) iodide; copper; potassium carbonate in toluene
Ullmann coupling; 24 h; Heating;
参考文献
Kenny, Jane R.; Maggs, James L.; Meng, Xiaoli; Sinnott, Deborah; Clarke, Stephen E.; Park, B. Kevin; Stachulski, Andrew V.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 11 p. 2816 - 2825
反应条件
1: 91 percent / K2CO3; CuI; Cu / toluene / 24 h / Heating
2: 90 percent / BBr3 / CH2Cl2; 1,2-dichloro-ethane / 20 °C
View Scheme
参考文献
Kenny, Jane R.; Maggs, James L.; Meng, Xiaoli; Sinnott, Deborah; Clarke, Stephen E.; Park, B. Kevin; Stachulski, Andrew V.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 11 p. 2816 - 2825
