3 - 甲基-3-（对甲苯磺酰氧基甲基）环氧丙烷合成路线 （共 12 条）
参考文献
Journal of Organic Chemistry, , vol. 63, # 11 p. 3631 - 3646
Tetrahedron, , vol. 57, # 8 p. 1497 - 1507
反应条件
1: 92 percent / NaBr / acetone / 30 h / Heating 2: 1.) Cs2CO3 / 1.) H2O, 20 min, 2.) DMF, room temperature, 24 h 3: 1.) BF3*Et2O, 2.) TEA / 1.) CH2Cl2, 0 deg C to room temperature, 6 h, 2.) 30 min View Scheme
参考文献
Liang, Xiaofei; Lee, Chul-Jin; Zhao, Jinshi; Toone, Eric J.; Zhou, Pei
Journal of Medicinal Chemistry, 2013 , vol. 56, # 17 p. 6954 - 6966
反应条件
sodium bromide in acetone 30 h; Heating;
参考文献
Samsung Electronics Co., Ltd.; Korea Advanced Institute of Science and Technology
Patent: EP1927592 A1, 2008 ;
Location in patent: Page/Page column 11 ;
反应条件
in N,N-dimethyl-formamide; mineral oil
参考文献
Aerojet General Corporation
Patent: US5807977 A1, 1998 ;
反应条件
in N,N-dimethyl-formamide; mineral oil
参考文献
Aerojet General Corporation
Patent: US5637772 A1, 1997 ;
反应条件
potassium iodide in N,N-dimethyl-formamide T=60°C; 7 h; Inert atmosphere;
参考文献
SUMITOMO CHEMICAL COMPANY, LIMITED; MATSUO, Noritada; OHSHITA, Jun
Patent: WO2012/133861 A1, 2012 ;
Location in patent: Page/Page column 210 ;
反应条件
sodium iodide in acetone 3 h; Heating;
参考文献
Tetrahedron, , vol. 58, # 35 p. 7049 - 7064
反应条件
1: 92 percent / NaBr / acetone / 30 h / Heating 2: 1.) Cs2CO3 / 1.) H2O, 20 min, 2.) DMF, room temperature, 24 h 3: 1.) BF3*Et2O, 2.) TEA / 1.) CH2Cl2, 0 deg C to room temperature, 6 h, 2.) 30 min View Scheme
参考文献
Blaskovich, Mark A.; Evindar, Ghotas; Rose, Nicholas G. W.; Wilkinson, Scott; Luo, Yue; Lajoie, Gilles A.
Journal of Organic Chemistry, 1998 , vol. 63, # 11 p. 3631 - 3646
反应条件
1: potassium iodide / N,N-dimethyl-formamide / 7 h / 60 °C / Inert atmosphere
2: hydrazine hydrate / methanol / 8 h / Inert atmosphere; Reflux
View Scheme
参考文献
SUMITOMO CHEMICAL COMPANY, LIMITED; MATSUO, Noritada; OHSHITA, Jun
Patent: WO2012/133861 A1, 2012 ;
反应条件
1: 92 percent / NaBr / acetone / 30 h / Heating
2: 1.) Cs2CO3 / 1.) H2O, 20 min, 2.) DMF, room temperature, 24 h
3: 1.) BF3*Et2O, 2.) TEA / 1.) CH2Cl2, 0 deg C to room temperature, 6 h, 2.) 30 min
View Scheme
参考文献
Blaskovich, Mark A.; Evindar, Ghotas; Rose, Nicholas G. W.; Wilkinson, Scott; Luo, Yue; Lajoie, Gilles A.
Journal of Organic Chemistry, 1998 , vol. 63, # 11 p. 3631 - 3646
