1,1-环己基二乙酸单酰胺合成路线 (共 4 条)
参考文献
Australian Journal of Chemistry, , vol. 13, p. 129 - 144
反应条件
1: With ammonia in water; acetic acid; toluene T=10 - 30°C; pH=> 8; 1.33333 h; 2: With hydrogenchloride in water T=40 - 45°C; pH=3.8 - 4.2; 0.333333 h;
参考文献
WO2005/44779 A2, ;
Page/Page column 6-7 ;
反应条件
1: With sodium hydroxide; sodium hypochlorite in water T=0 - 40°C; 3.5 h; 2: With hydrogenchloride in water T=100 - 105°C; pH=8.2 - 8.8; 3 h; Heating / reflux; Product distribution / selectivity;
参考文献
Zhejiang Chiral Medicine Chemicals Co., Ltd.
Patent: US2007/287861 A1, 2007 ;
Location in patent: Page/Page column 3-4 ;
反应条件
sodium carbonate in benzyl alcohol pH=7 - 7.5; Product distribution / selectivity;
参考文献
US2011/306787 A1, ;
Page/Page column 3 ;