1: formamide With potassium tert-butylate in dimethyl sulfoxide 0.5 h; 2: 4-chloro-1H-imidazo[4,5-c]-quinoline in dimethyl sulfoxide T=105°C; 2 h; 3: With hydrogenchloride in water; dimethyl sulfoxide pH=8; Product distribution / selectivity;
参考文献
FERRER INTERNACIONAL, S. A.
Patent: WO2006/100226 A1, 2006 ;
Location in patent: Page/Page column 8 ;
1: With sulfuric acid; water in dimethyl sulfoxide T=140°C; 20 h; 2: With sodium hydroxide; water in dimethyl sulfoxide T=20 - 60°C; pH=10 - 11; 2 h; Product distribution / selectivity;
1: formamide With potassium tert-butylate in isobutyramide 0.5 h; 2: 4-chloro-1H-imidazo[4,5-c]-quinoline in isobutyramide T=120°C; 1 h; Product distribution / selectivity;
